ArticlePloS one2012
Properties of the nucleo-olivary pathway: an in vivo whole-cell patch clamp study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor.Frontiers in neurology · 2021Pooled it
- Homeostatic bidirectional plasticity in upbound and downbound micromodules in a model of the olivocerebellar loop.PLoS computational biology · 2025Article
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- Cerebellar interpositus nucleus exhibits time-dependent errors and predictive responses.NPJ science of learning · 2024Article
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- Diversity and dynamism in the cerebellum.Nature neuroscience · 2021Review
- Red nucleus structure and function: from anatomy to clinical neurosciences.Brain structure & function · 2021Review
- Population coding in the cerebellum: a machine learning perspective.Journal of neurophysiology · 2020Review
- Electrical coupling controls dimensionality and chaotic firing of inferior olive neurons.PLoS computational biology · 2020Article
- Role of cerebellar GABAergic dysfunctions in the origins of essential tremor.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory.Scientific reports · 2019Article
- Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells.Scientific reports · 2019Article
- Delayed Complex Spike Response Evoked by Conditioned Stimulus Encodes Movement Onset Time and Is Determined by Intrinsic Inferior Olive Properties.Frontiers in systems neuroscience · 2019Article
- Cerebellar learning using perturbations.eLife · 2018Article
- Active integration of glutamatergic input to the inferior olive generates bidirectional postsynaptic potentials.The Journal of physiology · 2017Article
- The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper.Cerebellum (London, England) · 2017Article
- The dynamic relationship between cerebellar Purkinje cell simple spikes and the spikelet number of complex spikes.The Journal of physiology · 2017Article
- Synchronicity and Rhythmicity of Purkinje Cell Firing during Generalized Spike-and-Wave Discharges in a Natural Mouse Model of Absence Epilepsy.Frontiers in cellular neuroscience · 2017Article
- Electrical Coupling and Synchronized Subthreshold Oscillations in the Inferior Olive of the Rhesus Macaque.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inferior olivary nucleus (IO) forms the gateway to the cerebellar cortex and receives feedback information from the cerebellar nuclei (CN), thereby occupying a central position in the olivo-cerebellar loop. Here, we investigated the feedback input from the CN to the IO in vivo in mice using the whole-cell patch-clamp technique. This approach allows us to study how the CN-feedback input is integrated with the activity of olivary neurons, while the olivo-cerebellar system and its connections are intact. Our results show how IO neurons respond to CN stimulation sequentially with: i) a short depolarization (EPSP), ii) a hyperpolarization (IPSP) and iii) a rebound depolarization. The latter two phenomena can also be evoked without the EPSPs. The IPSP is sensitive to a GABA(A) receptor blocker. The IPSP suppresses suprathreshold and subthreshold activity and is generated mainly by activation of the GABA(A) receptors. The rebound depolarization re-initiates and temporarily phase locks the subthreshold oscillations. Lack of electrotonical coupling does not affect the IPSP of individual olivary neurons, nor the sensitivity of its GABA(A) receptors to blockers. The GABAergic feedback input from the CN does not only temporarily block the transmission of signals through the IO, it also isolates neurons from the network by shunting the junction current and re-initiates the temporal pattern after a fixed time point. These data suggest that the IO not only functions as a cerebellar controlled gating device, but also operates as a pattern generator for controlling motor timing and/or learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.