ArticlePloS one2012
H(2)S-releasing aspirin protects against aspirin-induced gastric injury via reducing oxidative stress.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Review on recent advancements in understanding acetylsalicylic acid-induced gastrointestinal injury: mechanisms, medication, and dosage refinement.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Pills of Multi-Target HInternational journal of molecular sciences · 2024Review
- Article
- ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis.Frontiers of medicine · 2023Article
- The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals.Antioxidants (Basel, Switzerland) · 2023Review
- Anticancer and Anti-Inflammatory Mechanisms of NOSH-Aspirin and Its Biological Effects.Computational and mathematical methods in medicine · 2022Review
- HBiomedicines · 2021Review
- Gaseous Mediators as a Key Molecular Targets for the Development of Gastrointestinal-Safe Anti-Inflammatory Pharmacology.Frontiers in pharmacology · 2021Review
- Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence.Nutrients · 2020Review
- A novel pH-controlled hydrogen sulfide donor protects gastric mucosa from aspirin-induced injury.Journal of cellular and molecular medicine · 2017Article
- Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs.Frontiers in chemistry · 2017Article
- Recent Development of Hydrogen Sulfide Releasing/Stimulating Reagents and Their Potential Applications in Cancer and Glycometabolic Disorders.Frontiers in pharmacology · 2017Review
- Hydrogen Sulfide in Renal Physiology and Disease.Antioxidants & redox signaling · 2016Review
- Hydrogen Sulfide in Physiology and Diseases of the Digestive Tract.Microorganisms · 2015Review
- Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing.Molecules (Basel, Switzerland) · 2015Review
- Sulfhydration of p66Shc at cysteine59 mediates the antioxidant effect of hydrogen sulfide.Antioxidants & redox signaling · 2014Article
- Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats.World journal of gastroenterology · 2014Article
- Anti-cancer activity of new designer hydrogen sulfide-donating hybrids.Antioxidants & redox signaling · 2014Review
- Preparation and characterization of a novel aspirin derivative with anti-thrombotic and gastric mucosal protection properties.PloS one · 2014Article
- Oxidative stress induces gastric submucosal arteriolar dysfunction in the elderly.World journal of gastroenterology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to examine the effect of ACS14, a hydrogen sulfide (H(2)S)-releasing derivative of aspirin (Asp), on Asp-induced gastric injury. Gastric hemorrhagic lesions were induced by intragastric administration of Asp (200 mg/kg, suspended in 0.5% carboxymethyl cellulose solutions) in a volume of 1 ml/100 g body weight. ACS14 (1, 5 or 10 mg/kg) was given 30 min before the Asp administration. The total area of gastric erosions, H(2)S concentration and oxidative stress in gastric tissues were measured three hours after administration of Asp. Treatment with Asp (200 mg/kg), but not ACS14 (430 mg/kg, at equimolar doses to 200 mg/kg Asp), for 3 h significantly increased gastric mucosal injury. The damage caused by Asp was reversed by ACS14 at 1-10 mg/kg in a concentration-dependent manner. ACS14 abrogated Asp-induced upregulation of COX-2 expression, but had no effect on the reduced PGE(2) level. ACS14 reversed the decreased H(2)S concentrations and blood flow in the gastric tissue in Asp-treated rats. Moreover, ACS14 attenuated Asp-suppressed superoxide dismutase-1 (SOD-1) expression and GSH activity, suggesting that ACS14 may stimulate antioxidants in the gastric tissue. ACS14 also obviously inhibited Asp-induced upregulation of protein expression of oxidases including XOD, p47(phox) and p67(phox). In conclusion, ACS14 protects Asp induced gastric mucosal injury by inhibiting oxidative stress in the gastric tissue.
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Registered trials
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