ArticlePloS one2012
Profiling the anaerobic response of C. elegans using GC-MS.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nonmammalian models to study Clostridioides difficile infection; a systematic review.Anaerobe · 2023Pooled it
- Transcriptional patterns of sexual dimorphism and in host developmental programs in the model parasitic nematode Heligmosomoides bakeri.Parasites & vectors · 2023Article
- Identification of enzymes that have helminth-specific active sites and are required for Rhodoquinone-dependent metabolism as targets for new anthelmintics.PLoS neglected tropical diseases · 2021Article
- Article
- Involvement of Spermidine in the Reduced Lifespan ofMetabolites · 2019Article
- Metabolomic profiling of the excretory-secretory products of hookworm and whipworm.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Rhodoquinone biosynthesis ineLife · 2019Article
- Tryptophan Metabolism in Caenorhabditis elegans Links Aggregation Behavior to Nutritional Status.ACS chemical biology · 2019Article
- A Caenorhabditis elegans Genome-Scale Metabolic Network Model.Cell systems · 2016Article
- Mitochondrial metabolites extend lifespan.Aging cell · 2016Article
- Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response.Cell death & disease · 2016Article
- Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy.Trends in endocrinology and metabolism: TEM · 2014Review
- The paradox of mitochondrial dysfunction and extended longevity.Experimental gerontology · 2014Review
- Article
- An anoxia-starvation model for ischemia/reperfusion in C. elegans.Journal of visualized experiments : JoVE · 2014Article
- In vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans.Molecular genetics and metabolism · 2014Article
- Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nematode Caenorhabditis elegans is a model organism that has seen extensive use over the last four decades in multiple areas of investigation. In this study we explore the response of the nematode Caenorhabditis elegans to acute anoxia using gas-chromatography mass-spectrometry (GC-MS). We focus on the readily-accessible worm exometabolome to show that C. elegans are mixed acid fermenters that utilize several metabolic pathways in unconventional ways to remove reducing equivalents - including partial reversal of branched-chain amino acid catabolism and a potentially novel use of the glyoxylate pathway. In doing so, we provide detailed methods for the collection and analysis of excreted metabolites that, with minimal adjustment, should be applicable to many other species. We also describe a procedure for collecting highly volatile compounds from C. elegans. We are distributing our mass spectral library in an effort to facilitate wider use of metabolomics.
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Registered trials
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