ArticlePloS one2012
Role of Abca7 in mouse behaviours relevant to neurodegenerative diseases.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome.Molecular psychiatry · 2025Article
- Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.Acta neuropathologica communications · 2023Article
- The role of ATP-binding cassette subfamily A in the etiology of Alzheimer's disease.Molecular neurodegeneration · 2022Review
- Sex-specific lipid dysregulation in theBrain communications · 2022Article
- Role of ABCA7 in Human Health and in Alzheimer's Disease.International journal of molecular sciences · 2021Review
- ABCA7 and the altered lipidostasis hypothesis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer's Disease.Frontiers in cellular neuroscience · 2020Article
- The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics.Acta neuropathologica · 2019Review
- ABCA7 Risk Genotype Diminishes the Neuroprotective Value of Aerobic Fitness in Healthy Older African Americans.Frontiers in aging neuroscience · 2019Article
- ABCA7 and Pathogenic Pathways of Alzheimer's Disease.Brain sciences · 2018Review
- Study on Lentivirus-Mediated ABCA7 Improves Neurocognitive Function and Related Mechanisms in the C57BL/6 Mouse Model of Alzheimer's Disease.Journal of molecular neuroscience : MN · 2017Article
- ABCA7 frameshift deletion associated with Alzheimer disease in African Americans.Neurology. Genetics · 2016Article
- ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons.Genes, brain, and behavior · 2016Article
- ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing.The Journal of biological chemistry · 2015Article
- ABCA7 in Alzheimer's Disease.Molecular neurobiology · 2015Review
- Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice.Psychopharmacology · 2014Article
- Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ATP-binding cassette transporters of the subfamily A (ABCA) are responsible for the translocation of lipids including cholesterol, which is crucial for neurological function. Recent studies suggest that the ABC transporter ABCA7 may play a role in the development of brain disorders such as schizophrenia and Alzheimer's disease. However, Abca7's role in cognition and other behaviours has not been investigated. Therefore, we characterised homozygous Abca7 knockout mice in a battery of tests for baseline behaviours (i.e. physical exam, baseline locomotion and anxiety) and behaviours relevant to schizophrenia (i.e. prepulse inhibition and locomotor response to psychotropic drugs) and Alzheimer's disease (i.e. cognitive domains). Knockout mice had normal motor functions and sensory abilities and performed the same as wild type-like animals in anxiety tasks. Short-term spatial memory and fear-associated learning was also intact in Abca7 knockout mice. However, male knockout mice exhibited significantly impaired novel object recognition memory. Task acquisition was unaffected in the cheeseboard task. Female mice exhibited impaired spatial reference memory. This phenomenon was more pronounced in female Abca7 null mice. Acoustic startle response, sensorimotor gating and baseline locomotion was unaltered in Abca7 knockout mice. Female knockouts showed a moderately increased motor response to MK-801 than control mice. In conclusion, Abca7 appears to play only a minor role in behavioural domains with a subtle sex-specific impact on particular cognitive domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.