ArticlePloS one2012
Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- HIF inhibition: Current strategies and clinical challenges.Redox biology · 2026Review
- The cistrome response to hypoxia in human umbilical vein endothelial cells.bioRxiv : the preprint server for biology · 2026Article
- Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF-dependent activation of hypoxia-inducible genes.The FEBS journal · 2025Article
- Oxidative Stress and Inflammation in Hypoxemic Respiratory Diseases and Their Comorbidities: Molecular Insights and Diagnostic Advances in Chronic Obstructive Pulmonary Disease and Sleep Apnea.Antioxidants (Basel, Switzerland) · 2025Review
- Hypoxic regulation of ADAMTS-2 and -3 (a disintegrin and matrix metalloproteinase with thrombospondin motifs 2 and 3) procollagen N proteinases by HIF-1α in endothelial cells.Molecular and cellular biochemistry · 2023Article
- Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis.Molecular psychiatry · 2022Article
- EBF1 promotes triple-negative breast cancer progression by surveillance of the HIF1α pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hypoxia-Inducible Factors and Burn-Associated Acute Kidney Injury-A New Paradigm?International journal of molecular sciences · 2022Review
- Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers.The Journal of clinical investigation · 2019Review
- Liver CEBPβ Modulates the Kynurenine Metabolism and Mediates the Motility for Hypoxia-Induced Central Fatigue in Mice.Frontiers in physiology · 2019Article
- BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.Breast cancer research : BCR · 2018Article
- Copper levels affect targeting of hypoxia-inducible factor 1α to the promoters of hypoxia-regulated genes.The Journal of biological chemistry · 2018Article
- The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia.Nucleic acids research · 2018Article
- The Transcription Factor Hif-1 Enhances the Radio-Resistance of Mouse MSCs.Frontiers in physiology · 2018Article
- Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer.Scientific reports · 2017Article
- Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia.Nucleic acids research · 2016Article
- HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival.Cell metabolism · 2016Article
- Article
- Gene expression network analysis reveals new transcriptional regulators as novel factors in human ischemic cardiomyopathy.BMC medical genomics · 2015Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcriptional response driven by Hypoxia-inducible factor (HIF) is central to the adaptation to oxygen restriction. Despite recent characterization of genome-wide HIF DNA binding locations and hypoxia-regulated transcripts in different cell types, the molecular bases of HIF target selection remain unresolved. Herein, we combined multi-level experimental data and computational predictions to identify sequence motifs that may contribute to HIF target selectivity. We obtained a core set of bona fide HIF binding regions by integrating multiple HIF1 DNA binding and hypoxia expression profiling datasets. This core set exhibits evolutionarily conserved binding regions and is enriched in functional responses to hypoxia. Computational prediction of enriched transcription factor binding sites identified sequence motifs corresponding to several stress-responsive transcription factors, such as activator protein 1 (AP1), cAMP response element-binding (CREB), or CCAAT-enhancer binding protein (CEBP). Experimental validations on HIF-regulated promoters suggest a functional role of the identified motifs in modulating HIF-mediated transcription. Accordingly, transcriptional targets of these factors are over-represented in a sorted list of hypoxia-regulated genes. Altogether, our results implicate cooperativity among stress-responsive transcription factors in fine-tuning the HIF transcriptional response.
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Registered trials
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