ArticlePloS one2012
Iron supplementation decreases severity of allergic inflammation in murine lung.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Causal relationship between iron deficiency anemia and asthma: a Mendelian randomization study.Frontiers in pediatrics · 2024Article
- Relationship between serum iron and blood eosinophil counts in asthmatic adults: data from NHANES 2011-2018.Frontiers in immunology · 2023Article
- Can Iron Play a Crucial Role in Maintaining Cardiovascular Health in the 21st Century?International journal of environmental research and public health · 2022Review
- Causal effect of iron status on lung function: A Mendelian randomization study.Frontiers in nutrition · 2022Article
- Association between Concentrations of Metals in Urine and Adult Asthma: A Case-Control Study in Wuhan, China.PloS one · 2016Article
- Retraction: Iron Supplementation Decreases Severity of Allergic Inflammation in Murine Lung.PloS one · 2016Article
- Perimenstrual asthma: from pathophysiology to treatment strategies.Multidisciplinary respiratory medicine · 2016Review
- A computational model of unresolved allergic inflammation in chronic asthma.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Association between Micronutrient Levels and Chronic Spontaneous Urticaria.BioMed research international · 2015Article
- Article
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Corrections and comments
- Retraction · 2016-05-09Concerns/Issues about Data · Error in Image · Error in Methods · Unreliable Data · Removed ·
- Commented on by
- Erratum issued
- Retracted
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The incidence and severity of allergic asthma have increased over the last century, particularly in the United States and other developed countries. This time frame was characterized by marked environmental changes, including enhanced hygiene, decreased pathogen exposure, increased exposure to inhaled pollutants, and changes in diet. Although iron is well-known to participate in critical biologic processes such as oxygen transport, energy generation, and host defense, iron deficiency remains common in the United States and world-wide. The purpose of these studies was to determine how dietary iron supplementation affected the severity of allergic inflammation in the lungs, using a classic model of IgE-mediated allergy in mice. Results showed that mice fed an iron-supplemented diet had markedly decreased allergen-induced airway hyperreactivity, eosinophil infiltration, and production of pro-inflammatory cytokines, compared with control mice on an unsupplemented diet that generated mild iron deficiency but not anemia. In vitro, iron supplementation decreased mast cell granule content, IgE-triggered degranulation, and production of pro-inflammatory cytokines post-degranulation. Taken together, these studies show that iron supplementation can decrease the severity of allergic inflammation in the lung, potentially via multiple mechanisms that affect mast cell activity. Further studies are indicated to determine the potential of iron supplementation to modulate the clinical severity of allergic diseases in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.