ArticlePloS one2012
Action of vitamin D and the receptor, VDRa, in calcium handling in zebrafish (Danio rerio).
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 77 citations in OpenAlex.
- Vitamin DApplied microbiology and biotechnology · 2026Review
- Sox10 is required for systemic initiation of bone mineralization.Development (Cambridge, England) · 2025Article
- Emerging role of vitamin DAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Fluorescent sensors for imaging of interstitial calcium.Nature communications · 2023Article
- Implications of vitamin D for flesh quality of grass carp (Ctenopharyngodon idella): antioxidant ability, nutritional value, sensory quality, and myofiber characteristics.Journal of animal science and biotechnology · 2023Article
- Piscine Vitamin D Receptors Vdra/Vdrb in the Absence of Vitamin D Are Utilized by Grass Carp Reovirus for Promoting Viral Replication.Microbiology spectrum · 2023Article
- Vitamin D Promotes Mucosal Barrier System of Fish Skin Infected withInternational journal of molecular sciences · 2023Article
- Enhanced insulin activity achieved in VDRa/b ablation zebrafish.Frontiers in endocrinology · 2023Article
- Zebrafish Models for Human Skeletal Disorders.Frontiers in genetics · 2021Review
- Overexpression of Notch Signaling Induces Hyperosteogeny in Zebrafish.International journal of molecular sciences · 2019Article
- Vitamin D Receptor Signaling Regulates Craniofacial Cartilage Development in Zebrafish.Journal of developmental biology · 2019Article
- Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish.Developmental cell · 2019Article
- Temperature-dependent vitamin D signaling regulates developmental trajectory associated with diapause in an annual killifish.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Diverse Regulation of Vitamin D Receptor Gene Expression by 1,25-Dihydroxyvitamin D and ATRA in Murine and Human Blood Cells at Early Stages of Their Differentiation.International journal of molecular sciences · 2017Article
- Development of a Whole Organism Platform for Phenotype-Based Analysis of IGF1R-PI3K-Akt-Tor Action.Scientific reports · 2017Article
- The Control of Calcium Metabolism in Zebrafish (Danio rerio).International journal of molecular sciences · 2016Review
- Article
- Environmental and cortisol-mediated control of Ca(2+) uptake in tilapia (Oreochromis mossambicus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation.Stem cell reports · 2015Article
- Hydrogen sulfide inhibits Na+ uptake in larval zebrafish, Danio rerio.Pflugers Archiv : European journal of physiology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the present study was to use zebrafish as a model to investigate how vitamin D and its receptors interact to control Ca(2+) uptake function. Low-Ca(2+) fresh water stimulated Ca(2+) influx and expressions of epithelial calcium channel (ecac), vitamin D-25-hydroxylase (cyp2r1), vitamin D receptor a (vdra), and vdrb in zebrafish. Exogenous vitamin D increased Ca(2+) influx and expressions of ecac and 25-hydroxyvitamin D(3)-24-hydroxylase (cyp24a1), but downregulated 1α-OHase (cyp27b1) with no effects on other Ca(2+) transporters. Morpholino oligonucleotide knockdown of VDRa, but not VDRb, was found as a consequence of calcium uptake inhibition by knockdown of ecac, and ossification of vertebrae is impaired. Taken together, vitamin D-VDRa signaling may stimulate Ca(2+) uptake by upregulating ECaC in zebrafish, thereby clarifying the Ca(2+)-handling function of only a VDR in teleosts. Zebrafish may be useful as a model to explore the function of vitamin D-VDR signaling in Ca(2+) homeostasis and the related physiological processes in vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.