SynthesisPloS one2012
Replication study in Chinese population and meta-analysis supports association of the 11q23 locus with colorectal cancer.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Evaluating the predictive value of genetic risk score in colorectal cancer among Chinese Han population.Journal of human genetics · 2020Article
- Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population.Oncotarget · 2017Article
- Negative to positive lymph node ratio is a superior predictor than traditional lymph node status in stage III colorectal cancer.Oncotarget · 2016Article
- Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis.Carcinogenesis · 2014Article
- Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.International journal of cancer · 2014Article
- Single nucleotide polymorphisms associated with colorectal cancer susceptibility and loss of heterozygosity in a Taiwanese population.PloS one · 2014Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA common single nucleotide polymorphism (SNP), rs3802842, located at 11q23, was identified by genome-wide association studies (GWAS) to be significantly associated with the risk of colorectal cancer (CRC); however, the results of following replication studies were not always concordant. Thus, a case-control study and a meta-analysis were performed to clearly discern the effect of this variant in CRC. METHOD AND
findingsWe determined the genotypes of rs3802842 in 641 unrelated Chinese patients with CRC and 1037 cancer-free controls. Additionally, a meta-analysis comprising current and previously published studies was conducted. In our case-control study, significant associations between the polymorphism and CRC risk were observed in all genetic models, with an additive OR being 1.45 (95% CI = 1.26-1.67). The meta-analysis of 38534 cases and 39446 controls further confirmed the significant associations in all genetic models but with obvious between-study heterogeneity. Nevertheless, ethnicity, study type and whether subjects affected by Lynch syndrome could synthetically accounted for the heterogeneity. Besides, the cumulative and sensitivity analyses indicated the robust stability of the results.
conclusionThe results from our case-control study and meta-analysis provided convincing evidence that rs3802842 significantly contributed to CRC risk.
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