ArticlePloS one2012
Dysregulation of the autonomous nervous system in patients with temporomandibular disorder: a pupillometric study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ANS Effects of ULF-TENS Stimulation in Patients With and Without TMD
The Effect of Application of Vagus Nerve Stimulation on the Treatment Efficiency in Temporomandibular Joint Dysfunction Caused by Myofascial Pain Syndrome
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Effects of trigeminal neurostimulation on heart rate variability: comparing cutaneous (Tragus) and tongue (Antero-Dorsal mucosa) stimulation.BMC oral health · 2024Trial
- A Device Improves Signs and Symptoms of TMD.Pain research & management · 2019Trial
- Comparison between sensory and motor transcutaneous electrical nervous stimulation on electromyographic and kinesiographic activity of patients with temporomandibular disorder: a controlled clinical trial.BMC musculoskeletal disorders · 2013Trial
- Association between primary Sjögren's disease and temporomandibular disorder in Taiwan: a 15-year nationwide cohort, with an exploratory analysis of hydroxychloroquine.BMC oral health · 2026Article
- Pupillary Hippus as a Biomarker: Spectral Signatures and Complexity Approaches in Autonomic and Clinical Contexts.Bioengineering (Basel, Switzerland) · 2025Review
- Eighty-Four-Month Clinical Outcomes of Autologous Dentin Graft Using Tooth TransformerJournal of functional biomaterials · 2025Article
- Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases.Orthopaedic surgery · 2025Review
- The relationship between dental occlusion and visual dysfunctions: A literature review.Journal of orthodontic science · 2025Review
- Tell me what to expect: how instructions affect the pain response of patients with chronic myofascial pain with referral.Journal of oral & facial pain and headache · 2024Article
- Impact of applying different levels of threshold-based artifact correction on the processing of heart rate variability data in individuals with temporomandibular disorder.Scientific reports · 2024Observational
- Neuromodulation as a Potential Disease-Modifying Therapy for Osteoarthritis.Current rheumatology reports · 2023Review
- Standard Correction of Vision Worsens EMG Activity of Pericranial Muscles in Chronic TMD Subjects.Pain research & management · 2020Article
- School environment associates with lung function and autonomic nervous system activity in children: a cross-sectional study.Scientific reports · 2019Article
- Central Sensitization-Based Classification for Temporomandibular Disorders: A Pathogenetic Hypothesis.Pain research & management · 2017Review
- Dental Occlusion and Ophthalmology: A Literature Review.The open dentistry journal · 2016Article
- Article
- Investigation of nonlinear pupil dynamics by recurrence quantification analysis.BioMed research international · 2013Article
- Craniomandibular disorders and mandibular reference position in orthodontic treatment.International journal of dentistry · 2013Review
- Psychosocial Scores and Jaw Muscle Activity in Women.Journal of oral & facial pain and headacheArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the autonomic nervous system (ANS) was recently investigated in Temporomandibular disorders (TMD). Several authors argue that in subjects with TMD there is a dysregulation of ANS. Recent literature support that Pupillometry is a simple non-invasive tool to study ANS. The aim of this study was to investigate the relationship between TMD and ANS activity using pupillometry recording in Infrared light at rest Mandible Position (RP); Infrared light at Forced Habitual Occlusion (FHO); Yellow-green light at RP; Yellow-green light at FHO. Forty female subjects were enrolled: 20 case patients showed TMD based on the Research Diagnostic Criteria for TMD, and 20 control patients, aged matched, had no signs or symptoms of TMD. Statistical analysis was performed on average pupil size. Ratio between pupil size in FHO and RP (FHO/RP ratio) and yellow-green and infrared (light/darkness ratio) lighting were carried out. Within group differences of pupil size and of "ratio" were analyzed using a paired t test, while differences of pupil size between groups were tested using an unpaired t test. Statistical comparisons between groups showed no significant differences of absolute values of pupil dimension in RP and FHO, both in yellow-green and in infrared lighting. In addition, there were no significant differences within groups comparing RP and FHO in yellow-green light. In within group comparison of pupil size, differences between RP and FHO were significant in infrared conditions. Control subjects increased, whereas TMD patients decreased pupil size at FHO in infrared lightening. FHO/RP ratio in darkness and light/darkness ratio in RP were significantly different between groups. Taken together, these data suggest that TMD subjects have an impairment of the sympathetic-adrenergic component of the ANS to be activated under stress. The present study provides preliminary pupillometric data confirming that adrenergic function is dysregulated in patients with TMD.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.