ArticlePloS one2012
Pathogenicity of Salmonella enterica in Caenorhabditis elegans relies on disseminated oxidative stress in the infected host.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
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- Curcumin Stimulates the Overexpression of Virulence Factors inAntibiotics (Basel, Switzerland) · 2022Article
- Activity of Essential Oils Against Multidrug-Resistant Salmonella enteritidis.Current microbiology · 2022Article
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- Proteomic analysis of Caenorhabditis elegans against Salmonella Typhi toxic proteins.Genes and immunity · 2021Article
- A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans.Current opinion in immunology · 2021Review
- MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa.European journal of cell biology · 2019Article
- Amplex Red Assay for Measuring Hydrogen Peroxide Production fromBio-protocol · 2019Article
- A novel approach to determine generalist nematophagous microbes reveals Mortierella globalpina as a new biocontrol agent against Meloidogyne spp. nematodes.Scientific reports · 2019Article
- Salmonella and Reactive Oxygen Species: A Love-Hate Relationship.Journal of innate immunity · 2019Review
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feeding Caenorhabditis elegans with Salmonella enterica serovar Typhimurium significantly shortens the lifespan of the nematode. S. Typhimurium-infected C. elegans, stained with 2',7'-dichlorodihydrofluorescein diacetate which fluoresces upon exposure to reactive oxygen species, revealed intestinal luminal staining that along with the time of infection progressed to a strong staining in the hypodermal tissues of the nematode. Still, we could not detect invasion beyond the nematode's intestinal epithelium at any stage of the infection. A similar dispersion of oxidative response was also noted in nematodes infected with S. Dublin, but not with non-pathogenic Escherichia coli or the defined pathogen Burkholderia thailandensis. Addition of catalase or the reductant ascorbic acid significantly restored the lifespan of S. Typhimurium-infected nematodes. Mutational inactivation of the bacterial thioredoxin 1 resulted in total ablation of the hypodermal oxidative response to infection, and in a strong attenuation of virulence. Virulence of the thioredoxin 1 mutant was restored by trans-complementation with redox-active variants of thioredoxin 1 or, surprisingly, by exposing the thioredoxin 1 mutant to sublethal concentrations of the disulphide catalyst copper chloride prior to infection. In summary, our observations define a new aspect in virulence of S. enterica that apparently does not involve the classical invasive or intracellular phenotype of the pathogen, but that depends on the ability to provoke overwhelming systemic oxidative stress in the host through the redox activity of bacterial thioredoxin 1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.