ArticlePloS one2012
Directional selection causes decanalization in a group I ribozyme.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Gene Regulatory Evolution in Cold-Adapted Fly Populations Neutralizes Plasticity and May Undermine Genetic Canalization.Genome biology and evolution · 2022Article
- Big on Change, Small on Innovation: Evolutionary Consequences of RNA Sequence Duplication.Journal of molecular evolution · 2019Article
- Directional selection reduces developmental canalization against genetic and environmental perturbations in Drosophila wings.Evolution; international journal of organic evolution · 2018Article
- Decanalization of wing development accompanied the evolution of large wings in high-altitude Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The effects of stabilizing and directional selection on phenotypic and genotypic variation in a population of RNA enzymes.Journal of molecular evolution · 2014Article
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Authors and funding
3 authors.
Funding
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Abstract
A canalized genotype is robust to environmental or genetic perturbations. Canalization is expected to result from stabilizing selection on a well-adapted phenotype. Decanalization, the loss of robustness, might follow periods of directional selection toward a new optimum. The evolutionary forces causing decanalization are still unknown, in part because it is difficult to determine the fitness effects of mutations in populations of organisms with complex genotypes and phenotypes. Here, we report direct experimental measurements of robustness in a system with a simple genotype and phenotype, the catalytic activity of an RNA enzyme. We find that the robustness of a population of RNA enzymes decreases during a period of directional selection in the laboratory. The decrease in robustness is primarily caused by the selective sweep of a genotype that is decanalized relative to the wild-type, both in terms of mutational robustness and environmental robustness (thermodynamic stability). Our results experimentally demonstrate that directional selection can cause decanalization on short time scales, and demonstrate co-evolution of mutational and environmental robustness.
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