ArticlePloS one2012
Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Medical gases and hypertensive disorders of pregnancy: therapeutic mechanisms and research advances.Medical gas research · 2027Review
- CaBiomedical reports · 2024Article
- Enhanced Nitrite-Mediated Relaxation of Placental Blood Vessels Exposed to Hypoxia Is Preserved in Pregnancies Complicated by Fetal Growth Restriction.International journal of molecular sciences · 2021Article
- Nitrite mediated vasorelaxation in human chorionic plate vessels is enhanced by hypoxia and dependent on the NO-sGC-cGMP pathway.Nitric oxide : biology and chemistry · 2018Article
- Early onset fetal growth restriction.Maternal health, neonatology and perinatology · 2017Review
- Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Observational
- S-Nitrosylated fetal hemoglobin in neonatal human blood.Biochemical and biophysical research communications · 2016Article
- Dysregulated flow-mediated vasodilatation in the human placenta in fetal growth restriction.The Journal of physiology · 2015Article
- Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity.American journal of physiology. Endocrinology and metabolism · 2015Article
- Estetrol Modulates Endothelial Nitric Oxide Synthesis in Human Endothelial Cells.Frontiers in endocrinology · 2015Article
- Plasma levels of dimethylarginines in preterm very low birth weight neonates: its relation with perinatal factors and short-term outcome.International journal of molecular sciences · 2014Article
- New insights on effects of a dietary supplement on oxidative and nitrosative stress in humans.Food science & nutrition · 2014Article
- Maternal melatonin administration mitigates coronary stiffness and endothelial dysfunction, and improves heart resilience to insult in growth restricted lambs.The Journal of physiology · 2014Article
- Is asymmetric dimethylarginine associated with being born small and large for gestational age?Antioxidants & redox signaling · 2014Review
- Effect of prenatal hypoxia in transgenic mouse models of preeclampsia and fetal growth restriction.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Feto-placental vascular dysfunction as a prenatal determinant of adult cardiovascular disease.Internal and emergency medicine · 2013Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally, demonstrate any abnormality in the nitric oxide system.
methodsPrenatal assessment of feto-placental vascular function was combined with measurement of nitric oxide (in the form of S-nitrosohemoglobin) and its nitrite byproduct, and of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine. Umbilical vein endothelial cells were also harvested to determine their gene profile. The study comprised term pregnancies with normal (n = 40) or small-for-gestational-age (n = 20) newborns, small-for-gestational-age preterm pregnancies (n = 15), and bi-chorial, bi-amniotic twin pregnancies with discordant fetal growth (n = 12).
resultsUmbilical blood nitrite (p<0.001) and S-nitrosohemoglobin (p = 0.02) rose with fetal growth restriction while asymmetric dimethylarginine decreased (p = 0.003). Nitrite rise coincided with an abnormal Doppler profile from umbilical arteries. Fetal growth restriction umbilical vein endothelial cells produced more nitrite and also exhibited reciprocal changes in vasodilator (upwards) and vasoconstrictor (downwards) transcripts. Elevation in blood nitrite and S-nitrosohemoglobin persisted postnatally in the fetal growth restriction offspring.
conclusionFetal growth restriction is typified by increased nitric oxide production during pregnancy and after birth. This response is viewed as an adaptative event to sustain placental blood flow. However, its occurrence may modify the endothelial phenotype and may ultimately represent an element of risk for cardiovascular disease in adult life.
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