ArticlePloS one2012
A comparative analysis of glomerulus development in the pronephros of medaka and zebrafish.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 15. Fish urinary system.Journal of toxicologic pathology · 2026Article
- The differential expression of MAGI2 in glomerulopathies and its application as a molecular discriminator of podocytopathies.Journal of translational medicine · 2025Article
- Effects of the environment on the evolution of the vertebrate urinary tract.Nature reviews. Urology · 2023Review
- Basement membrane defects in CD151-associated glomerular disease.Pediatric nephrology (Berlin, Germany) · 2022Article
- Article
- Zebrafish Vascular Mural Cell Biology: Recent Advances, Development, and Functions.Life (Basel, Switzerland) · 2021Review
- The human nephrin YThe Journal of biological chemistry · 2019Article
- Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model.Physiological reports · 2019Article
- Corticosteroid treatment exacerbates nephrotic syndrome in a zebrafish model of magi2a knockout.Kidney international · 2019Article
- Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish.Scientific reports · 2019Article
- Investigating the RAS can be a fishy business: interdisciplinary opportunities using Zebrafish.Clinical science (London, England : 1979) · 2018Review
- Article
- Novel Microscopic Techniques for Podocyte Research.Frontiers in endocrinology · 2018Review
- Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish.Molecular medicine reports · 2016Article
- Workshop report: The medaka model for comparative assessment of human disease mechanisms.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Article
- Using zebrafish to study podocyte genesis during kidney development and regeneration.Genesis (New York, N.Y. : 2000) · 2014Review
- Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros.Molecular medicine reports · 2014Article
- Podocalyxin regulates pronephric glomerular development in zebrafish.Physiological reports · 2013Article
- Developmental localization of nephrin in zebrafish and medaka pronephric glomerulus.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy.Biochemical and biophysical research communications · 2013Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
The glomerulus of the vertebrate kidney links the vasculature to the excretory system and produces the primary urine. It is a component of every single nephron in the complex mammalian metanephros and also in the primitive pronephros of fish and amphibian larvae. This systematic work highlights the benefits of using teleost models to understand the pronephric glomerulus development. The morphological processes forming the pronephric glomerulus are astoundingly different between medaka and zebrafish. (1) The glomerular primordium of medaka - unlike the one of zebrafish - exhibits a C-shaped epithelial layer. (2) The C-shaped primordium contains a characteristic balloon-like capillary, which is subsequently divided into several smaller capillaries. (3) In zebrafish, the bilateral pair of pronephric glomeruli is fused at the midline to form a glomerulus, while in medaka the two parts remain unmerged due to the interposition of the interglomerular mesangium. (4) Throughout pronephric development the interglomerular mesangial cells exhibit numerous cytoplasmic granules, which are reminiscent of renin-producing (juxtaglomerular) cells in the mammalian afferent arterioles. Our systematic analysis of medaka and zebrafish demonstrates that in fish, the morphogenesis of the pronephric glomerulus is not stereotypical. These differences need be taken into account in future analyses of medaka mutants with glomerulus defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.