ArticlePloS one2012
On-lattice simulation of T cell motility, chemotaxis, and trafficking in the lymph node paracortex.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Bigger is faster in the adaptive immune response.Scientific reports · 2025Article
- ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritis.Biomaterials science · 2024Article
- Computational fluid dynamic modeling of the lymphatic system: a review of existing models and future directions.Biomechanics and modeling in mechanobiology · 2024Review
- New tools for immunologists: models of lymph node function from cells to tissues.Frontiers in immunology · 2023Review
- Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system.Materials today. Bio · 2022Review
- Lymph node swelling combined with temporary effector T cell retention aids T cell response in a model of adaptive immunity.Journal of the Royal Society, Interface · 2021Article
- Live-Cell Microscopy Reveals That Human T Cells Primarily Respond Chemokinetically Within a CCL19 Gradient That Induces Chemotaxis in Dendritic Cells.Frontiers in immunology · 2021Article
- Modeling aerotaxis band formation in Azospirillum brasilense.BMC microbiology · 2019Article
- Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment.Processes (Basel, Switzerland) · 2019Article
- Review of the systems biology of the immune system using agent-based models.IET systems biology · 2018Review
- AnJournal of the Royal Society, Interface · 2018Article
- Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape.Frontiers in immunology · 2018Review
- A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Leukocyte Motility Models Assessed through Simulation and Multi-objective Optimization-Based Model Selection.PLoS computational biology · 2016Article
- A virtual lymph node model to dissect the requirements for T-cell activation by synapses and kinapses.Immunology and cell biology · 2016Article
- Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes.Lymphatic research and biology · 2015Article
- Harnessing the heterogeneity of T cell differentiation fate to fine-tune generation of effector and memory T cells.Frontiers in immunology · 2014Article
- Predicting lymph node output efficiency using systems biology.Journal of theoretical biology · 2013Article
- The future of immunoimaging--deeper, bigger, more precise, and definitively more colorful.European journal of immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Agent-based simulation is a powerful method for investigating the complex interplay of the processes occurring in a lymph node during an adaptive immune response. We have previously established an agent-based modeling framework for the interactions between T cells and dendritic cells within the paracortex of lymph nodes. This model simulates in three dimensions the "random-walk" T cell motility observed in vivo, so that cells interact in space and time as they process signals and commit to action such as proliferation. On-lattice treatment of cell motility allows large numbers of densely packed cells to be simulated, so that the low frequency of T cells capable of responding to a single antigen can be dealt with realistically. In this paper we build on this model by incorporating new numerical methods to address the crucial processes of T cell ingress and egress, and chemotaxis, within the lymph node. These methods enable simulation of the dramatic expansion and contraction of the T cell population in the lymph node paracortex during an immune response. They also provide a novel probabilistic method to simulate chemotaxis that will be generally useful in simulating other biological processes in which chemotaxis is an important feature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.