ArticlePloS one2012
Metastable differentially methylated regions within Arabidopsis inbred populations are associated with modified expression of non-coding transcripts.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Grain-maturing temperature induces seed epi-memory via DNA methylation for subsequent development in rice (Oryza sativa L.).Plant physiology · 2026Article
- Identification of epigenetically regulated genes involved in plant-virus interaction and their role in virus-triggered induced resistance.BMC plant biology · 2024Article
- Epigenetic Changes Occurring in Plant Inbreeding.International journal of molecular sciences · 2023Review
- Genomic impact of stress-induced transposable element mobility in Arabidopsis.Nucleic acids research · 2021Article
- Arabidopsis shoot stem cells display dynamic transcription and DNA methylation patterns.The EMBO journal · 2020Article
- EFFECTOR OF TRANSCRIPTION factors are novel plant-specific regulators associated with genomic DNA methylation in Arabidopsis.The New phytologist · 2019Article
- A Multigenic Network of ARGONAUTE4 Clade Members Controls Early Megaspore Formation in Arabidopsis.Genetics · 2016Article
- A Short Open Reading Frame Encompassing the MicroRNA173 Target Site Plays a Role in trans-Acting Small Interfering RNA Biogenesis.Plant physiology · 2016Article
- Mobile small RNAs regulate genome-wide DNA methylation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Information Thermodynamics of Cytosine DNA Methylation.PloS one · 2016Article
- Epigenetic regulation in plant responses to the environment.Cold Spring Harbor perspectives in biology · 2014Review
- Epigenetics: Beyond Chromatin Modifications and Complex Genetic Regulation.Plant physiology · 2014Review
- Inheritance patterns and stability of DNA methylation variation in maize near-isogenic lines.Genetics · 2014Article
- High-throughput sequencing of cytosine methylation in plant DNA.Plant methods · 2013Article
- Functional Characterisation of Alternative Oxidase Protein Isoproteins in Arabidopsis thaliana.Physiologia plantarumArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual plants within a population may vary at both genetic and epigenetic levels. The rate of genetic divergence and its underlying mechanisms is well understood. Less is known about the factors contributing to epigenetic divergence among isogenic populations except that, despite the presence of mechanisms that faithfully maintain epigenetic marks, epigenetic differences are more frequent than genetic variation. Epigenetically divergent stretches of isogenic DNA sequence are called epialleles. Currently, it is not clear why certain regions exhibit variable epigenetic status. We identified and characterised two long RNA transcripts with altered expression and DNA methylation in an ago5 mutant. However, further investigation revealed that these changes were not dependent upon AGO5. Rather, the variable transcription of these loci in Arabidopsis mutant and wild-type populations corresponds to spontaneous differential methylated regions (DMRs) or epialleles. These two DMRs are delineated by RNAs which are highly expressed when the DMR is hypomethylated. Furthermore, they control the expression of 5' transcriptional start site mRNA variants of nearby protein coding genes. Our data support the recent observations that meiotically stable DMRs exist within inbred populations. We further demonstrate that DMR boundaries can be defined by putative non-coding promoter-associated transcripts.
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