ArticlePloS one2012
Study of natural health product adverse reactions (SONAR): active surveillance of adverse events following concurrent natural health product and prescription drug use in community pharmacies.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- A multi-center cross-sectional study of Chinese Herbal Medicine-Drug adverse reactions using active surveillance in Singapore's Traditional Chinese Medicine clinics.Chinese medicine · 2024Article
- Study of Natural Products Adverse Reactions (SONAR) in Adults with Mental Health Conditions: A Cross-Sectional Study.Drug safety · 2021Article
- Article
- Patient safety in chiropractic teaching programs: a mixed methods study.Chiropractic & manual therapies · 2020Article
- Study of Natural products Adverse Reactions (SONAR) in children seen in mental health clinics: a cross-sectional study.BMJ paediatrics open · 2020Article
- Analysis of Hepatobiliary Disorder Reports Associated With the Use of Herbal Medicines in the Global Suspected ADR Database Vigibase.Frontiers in pharmacology · 2019Article
- Integration of botanicals in contemporary medicine: road blocks, checkpoints and go-ahead signals.Integrative medicine research · 2018Review
- Becoming a 'pharmaceutical person': Medication use trajectories from age 26 to 38 in a representative birth cohort from Dunedin, New Zealand.SSM - population health · 2018Article
- Guidance for establishing an integrative oncology service in the Australian healthcare setting-a discussion paper.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Development of an adverse events reporting form for Korean folk medicine.Pharmacoepidemiology and drug safety · 2017Article
- Natural health product-drug interaction tool: A scoping review.Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC · 2016Article
- The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring.Burns & trauma · 2016Review
- Damascenine induced hepatotoxicity and nephrotoxicity in mice and in vitro assessed human erythrocyte toxicity.Interdisciplinary toxicology · 2015Article
- A survey of the availability in Canadian pharmacy chains of over-the-counter natural health products for menopause symptoms.BMC complementary and alternative medicine · 2015Article
- Thyroid storm caused by a chinese herb contaminated with thyroid hormones.The American journal of case reports · 2015Article
- Concurrent use of drugs and supplements in a community-dwelling population aged 50 years or more: potential benefits and risks.Drugs & aging · 2014Article
- Article
- How well do pharmacists know their patients? A case report highlighting natural health product disclosure.Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC · 2013Article
- The use of natural health products by paediatric patients in respite care.Paediatrics & child healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundMany consumers use natural health products (NHPs) concurrently with prescription medications. As NHP-related harms are under-reported through passive surveillance, the safety of concurrent NHP-drug use remains unknown. To conduct active surveillance in participating community pharmacies to identify adverse events related to concurrent NHP-prescription drug use. METHODOLOGY/PRINCIPAL
findingsParticipating pharmacists asked individuals collecting prescription medications about (i) concurrent NHP/drug use in the previous three months and (ii) experiences of adverse events. If an adverse event was identified and if the patient provided written consent, a research pharmacist conducted a guided telephone interview to gather additional information after obtaining additional verbal consent and documenting so within the interview form. Over a total of 112 pharmacy weeks, 2615 patients were screened, of which 1037 (39.7%; 95% CI: 37.8% to 41.5%) reported concurrent NHP and prescription medication use. A total of 77 patients reported a possible AE (2.94%; 95% CI: 2.4% to 3.7%), which represents 7.4% of those using NHPs and prescription medications concurrently (95%CI: 6.0% to 9.2%). Of 15 patients available for an interview, 4 (26.7%: 95% CI: 4.3% to 49.0%) reported an AE that was determined to be "probably" due to NHP use. CONCLUSIONS/SIGNIFICANCE: Active surveillance markedly improves identification and reporting of adverse events associated with concurrent NHP-drug use. Although not without challenges, active surveillance is feasible and can generate adverse event data of sufficient quality to allow for meaningful adjudication to assess potential harms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.