ArticlePloS one2012
Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells.Epigenetics · 2024Article
- TET3-overexpressing macrophages promote endometriosis.The Journal of clinical investigation · 2024Article
- MeCP2 Is an Epigenetic Factor That Links DNA Methylation with Brain Metabolism.International journal of molecular sciences · 2023Review
- Structure and Function of TET Enzymes.Advances in experimental medicine and biology · 2022Article
- Tracing TET1 expression in prostate cancer: discovery of malignant cells with a distinct oncogenic signature.Clinical epigenetics · 2021Article
- Selectivity and Promiscuity in TET-Mediated Oxidation of 5-Methylcytosine in DNA and RNA.Biochemistry · 2019Article
- SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.Cell stem cell · 2018Article
- In vivo reprogramming drives Kras-induced cancer development.Nature communications · 2018Article
- The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development.Oncotarget · 2016Review
- An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development.Stem cell reports · 2016Article
- Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons.Nature communications · 2015Article
- DNA methylation and hydroxymethylation in hematologic differentiation and transformation.Current opinion in cell biology · 2015Review
- Functions of TET Proteins in Hematopoietic Transformation.Molecules and cells · 2015Review
- TET proteins and the control of cytosine demethylation in cancer.Genome medicine · 2015Article
- Molecules and mechanisms controlling the active DNA demethylation of the mammalian zygotic genome.Protein & cell · 2014Review
- A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxymethylcytosine levels.Veterinary research · 2014Article
- TET2 as an epigenetic master regulator for normal and malignant hematopoiesis.Cancer science · 2014Review
- Tet-mediated formation of 5-hydroxymethylcytosine in RNA.Journal of the American Chemical Society · 2014Article
- The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases.Leukemia · 2014Review
- Krüppel like factor 4 promoter undergoes active demethylation during monocyte/macrophage differentiation.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation-induced cytidine deminase (Aid), a unique enzyme that deaminates cytosine in DNA, shuttles between the nucleus and the cytoplasm. A recent study proposed a novel function of Aid in active DNA demethylation via deamination of 5-hydroxymethylcytosine, which is converted from 5-methylcytosine by the Ten-eleven translocation (Tet) family of enzymes. In this study, we examined the effect of simultaneous expression of Aid and Tet family proteins on the subcellular localization of each protein. We found that overexpressed Aid is mainly localized in the cytoplasm, whereas Tet1 and Tet2 are localized in the nucleus, and Tet3 is localized in both the cytoplasm and the nucleus. However, nuclear Tet proteins were gradually translocated to the cytoplasm when co-expressed with Aid. We also show that Aid-mediated translocation of Tet proteins is associated with Aid shuttling. Here we propose a possible role for Aid as a regulator of the subcellular localization of Tet family proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.