ArticlePloS one2012
P. falciparum infection durations and infectiousness are shaped by antigenic variation and innate and adaptive host immunity in a mathematical model.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
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- Diagnostic performance of an ultra-sensitive RDT and a conventional RDT in malaria mass testing, treatment and tracking interventions in southern Ghana.Parasites & vectors · 2024Article
- Spatial dynamics of malaria transmission.PLoS computational biology · 2023Article
- Application of mathematical modelling to inform national malaria intervention planning in Nigeria.Malaria journal · 2023Article
- Patient variability in the blood-stage dynamics of Plasmodium falciparum captured by clustering historical data.Malaria journal · 2022Article
- Infection age as a predictor of epidemiological metrics for malaria.Malaria journal · 2022Article
- Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malaria.Nature communications · 2021Article
- Mechanistic within-host models of the asexual Plasmodium falciparum infection: a review and analytical assessment.Malaria journal · 2021Article
- Histamine Ingestion byBiomolecules · 2021Article
- HIV-1 Infection Is Associated With Increased Prevalence and Abundance ofFrontiers in cellular and infection microbiology · 2020Article
- Using two phases of the CD4 T cell response to blood-stage murine malaria to understand regulation of systemic immunity and placental pathology in Plasmodium falciparum infection.Immunological reviews · 2020Review
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- Implementation and applications of EMOD, an individual-based multi-disease modeling platform.Pathogens and disease · 2018Article
- A whole parasite transmission-blocking vaccine for malaria: an ignored strategy.Emerging topics in life sciences · 2017Article
- Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling.Nature communications · 2017Article
- malERA: An updated research agenda for combination interventions and modelling in malaria elimination and eradication.PLoS medicine · 2017Review
- Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study.The Lancet. Global health · 2017Article
- Article
- Malaria Elimination Campaigns in the Lake Kariba Region of Zambia: A Spatial Dynamical Model.PLoS computational biology · 2016Article
- A computational lens for sexual-stage transmission, reproduction, fitness and kinetics in Plasmodium falciparum.Malaria journal · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many questions remain about P. falciparum within-host dynamics, immunity, and transmission-issues that may affect public health campaign planning. These gaps in knowledge concern the distribution of durations of malaria infections, determination of peak parasitemia during acute infection, the relationships among gametocytes and immune responses and infectiousness to mosquitoes, and the effect of antigenic structure on reinfection outcomes. The present model of intra-host dynamics of P. falciparum implements detailed representations of parasite and immune dynamics, with structures based on minimal extrapolations from first-principles biology in its foundations. The model is designed to quickly and readily accommodate gains in mechanistic understanding and to evaluate effects of alternative biological hypothesis through in silico experiments. Simulations follow the parasite from the liver-stage through the detailed asexual cycle to clearance while tracking gametocyte populations. The modeled immune system includes innate inflammatory and specific antibody responses to a repertoire of antigens. The mechanistic focus provides clear explanations for the structure of the distribution of infection durations through the interaction of antigenic variation and innate and adaptive immunity. Infectiousness to mosquitoes appears to be determined not only by the density of gametocytes but also by the level of inflammatory cytokines, which harmonizes an extensive series of study results. Finally, pre-existing immunity can either decrease or increase the duration of infections upon reinfection, depending on the degree of overlap in antigenic repertoires and the strength of the pre-existing immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.