ArticlePloS one2012
"Seed-Milarity" confers to hsa-miR-210 and hsa-miR-147b similar functional activity.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- MicroRNA-210-3p Regulates Endometriotic Lesion Development by Targeting IGFBP3 in Baboons and Women with Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Clinical association and diagnostic significance of miRNA-29a and miRNA-147b in type 2 diabetes mellitus.International journal of medical sciences · 2023Article
- Downregulation of miR-210 Promoted Apoptosis of Hippocampal Neurons by Negatively Regulating the TLR4/NF-кB1 Signaling Pathway in a Rat Model of Status Epilepticus.Neuropsychiatric disease and treatment · 2022Article
- Inflammation causes remodeling of mitochondrial cytochromeScience advances · 2021Article
- Evolving Schema for Employing Network Biology Approaches to Understand Pulmonary Hypertension.Advances in experimental medicine and biology · 2021Article
- Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.PLoS biology · 2020Article
- miR-147a suppresses the metastasis of non-small-cell lung cancer by targetingThe Journal of international medical research · 2020Article
- miR-147b-modulated expression of vestigial regulates wing development in the bird cherry-oat aphid Rhopalosiphum padi.BMC genomics · 2020Article
- Sodium new houttuyfonate suppresses metastasis in NSCLC cells through the Linc00668/miR-147a/slug axis.Journal of experimental & clinical cancer research : CR · 2019Article
- Article
- miR‑647 and miR‑1914 promote cancer progression equivalently by downregulating nuclear factor IX in colorectal cancer.Molecular medicine reports · 2017Article
- HOXD-AS1 functions as an oncogenic ceRNA to promote NSCLC cell progression by sequestering miR-147a.OncoTargets and therapy · 2017Article
- Intact feto-placental growth in microRNA-210 deficient mice.Placenta · 2016Article
- Insights into the post-transcriptional regulation of the mitochondrial electron transport chain.Biochemical Society transactions · 2016Review
- A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1α.Cancer biology & therapy · 2016Article
- Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development.Neural development · 2016Article
- Inverse relationship between microRNA-155 and -184 expression with increasing conjunctival inflammation during ocular Chlamydia trachomatis infection.BMC infectious diseases · 2016Article
- miR-9 Acts as an OncomiR in Prostate Cancer through Multiple Pathways That Drive Tumour Progression and Metastasis.PloS one · 2016Article
- MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen.Cancer cell international · 2016Article
- Trachoma and Ocular Chlamydial Infection in the Era of Genomics.Mediators of inflammation · 2015Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specificity of interaction between a microRNA (miRNA) and its targets crucially depends on the seed region located in its 5'-end. It is often implicitly considered that two miRNAs sharing the same biological activity should display similarity beyond the strict six nucleotide region that forms the seed, in order to form specific complexes with the same mRNA targets. We have found that expression of hsa-miR-147b and hsa-miR-210, though triggered by different stimuli (i.e. lipopolysaccharides and hypoxia, respectively), induce very similar cellular effects in term of proliferation, migration and apoptosis. Hsa-miR-147b only shares a "minimal" 6-nucleotides seed sequence with hsa-miR-210, but is identical with hsa-miR-147a over 20 nucleotides, except for one base located in the seed region. Phenotypic changes induced after heterologous expression of miR-147a strikingly differ from those induced by miR-147b or miR-210. In particular, miR-147a behaves as a potent inhibitor of cell proliferation and migration. These data fit well with the gene expression profiles observed for miR-147b and miR-210, which are very similar, and the gene expression profile of miR-147a, which is distinct from the two others. Bioinformatics analysis of all human miRNA sequences indicates multiple cases of miRNAs from distinct families exhibiting the same kind of similarity that would need to be further characterized in terms of putative functional redundancy. Besides, it implies that functional impact of some miRNAs can be masked by robust expression of miRNAs belonging to distinct families.
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