Evidence map›Paper›PMID 23028647›Full record

ArticlePloS one2012

Clinical disorders in a post war British cohort reaching retirement: evidence from the First National Birth Cohort study.

Mary B Pierce, Richard J Silverwood, Dorothea Nitsch, Judith E Adams, Alison M Stephen, Wing Nip, Peter Macfarlane, Andrew Wong, Marcus Richards, Rebecca Hardy and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 32 citations in OpenAlex.

  1. Age at Onset of Walking in Infancy Is Associated With Hip Shape in Early Old Age.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Mary B PierceMRC Unit for Lifelong Health & Ageing, London, England. m.pierce@nshd.mrc.ac.uk
Richard J Silverwood
Dorothea Nitsch
Judith E Adams
Alison M Stephen
Wing Nip
Peter Macfarlane
Andrew Wong
Marcus Richards
Rebecca Hardy
Diana Kuh
NSHD Scientific and Data Collection Teams
MRC Unit for Lifelong Health and Ageing · GBLondon School of Hygiene & Tropical Medicine · GBMRC Human Nutrition Research · GBManchester Academic Health Science Centre · GBUniversity of Glasgow · GB

Funding

Medical Research Council MC_U105960384Medical Research Council MC_U123092720Medical Research Council U1200632239Medical Research Council U123092720
6 · The paper itself

Abstract

backgroundThe medical needs of older people are growing because the proportion of the older population is increasing and disease boundaries are widening. This study describes the distribution and clustering of 15 common clinical disorders requiring medical treatment or supervision in a representative British cohort approaching retirement, and how health tracked across adulthood. METHODS AND

findingsThe data come from a cohort of 2661 men and women, 84% of the target sample, followed since birth in England, Scotland and Wales in 1946, and assessed at 60-64 years for: cardio and cerebro-vascular disease, hypertension, raised cholesterol, renal impairment, diabetes, obesity, hypothyroidism, hyperthyroidism, anaemia, respiratory disease, liver disease, psychiatric problems, cancers, atrial fibrillation on ECG and osteoporosis. We calculated the proportions disorder-free, with one or more disorders, and the level of undiagnosed disorders; and how these disorders cluster into latent classes and relate to health assessed at 36 years. Participants had, on average, two disorders (range 0-9); only 15% were disorder-free. The commonest disorders were hypertension (54.3%, 95% CI 51.8%-56.7%), obesity (31.1%, 28.8%-33.5%), raised cholesterol (25.6%, 23.1-28.26%), and diabetes or impaired fasting glucose (25.0%, 22.6-27.5%). A cluster of one in five individuals had a high probability of cardio-metabolic disorders and were twice as likely than others to have been in the poorest health at 36 years. The main limitations are that the native born sample is entirely white, and a combination of clinical assessments and self reports were used.

conclusionsMost British people reaching retirement already have clinical disorders requiring medical supervision. Widening disease definitions and the move from a disease-based to a risk-based medical model will increase pressure on health services. The promotion of healthy ageing should start earlier in life and consider the individual's ability to adapt to and self manage changes in health.

Indexed as

DiseaseParturitionWorld War IIAdultAge DistributionCluster AnalysisCohort StudiesEnglandFemaleHealth StatusHumansMaleMiddle AgedRetirementSelf ReportSex Distribution

Identifiers

PMID23028647
PMCPMC3447001
OpenAlexW2169166571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.