ArticlePloS one2012
Clinical disorders in a post war British cohort reaching retirement: evidence from the First National Birth Cohort study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 32 citations in OpenAlex.
- Age at Onset of Walking in Infancy Is Associated With Hip Shape in Early Old Age.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Trial
- Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort.BMC research notes · 2026Article
- Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Article
- A population-based study of head injury, cognitive function and pathological markers.Annals of clinical and translational neurology · 2021Article
- Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort.JAMA neurology · 2020Article
- Observational
- Obesity and Polypharmacy among African American Older Adults: Gender as the Moderator and Multimorbidity as the Mediator.International journal of environmental research and public health · 2019Article
- Associations between Polypharmacy, Self-Rated Health, and Depression in African American Older Adults; Mediators and Moderators.International journal of environmental research and public health · 2019Article
- Race/Ethnicity, Socioeconomic Status, and Polypharmacy among Older Americans.Pharmacy (Basel, Switzerland) · 2019Article
- Polypharmacy in African American Adults: A National Epidemiological Study.Pharmacy (Basel, Switzerland) · 2019Article
- Polypharmacy and Psychological Distress May Be Associated in African American Adults.Pharmacy (Basel, Switzerland) · 2019Article
- The prevalence and determinants of polypharmacy at age 69: a British birth cohort study.BMC geriatrics · 2018Article
- Apolipoprotein-E (Apoe) ε4 and cognitive decline over the adult life course.Translational psychiatry · 2018Article
- The Inherent Human Aging Process and the Facilitating Role of Exercise.Frontiers in physiology · 2018Review
- Declining performance of master athletes: silhouettes of the trajectory of healthy human ageing?The Journal of physiology · 2017Review
- From paediatrics to geriatrics: a life course perspective on the MRC National Survey of Health and Development.European journal of epidemiology · 2016Article
- The MRC National Survey of Health and Development reaches age 70: maintaining participation at older ages in a birth cohort study.European journal of epidemiology · 2016Article
- Pubertal timing and bone phenotype in early old age: findings from a British birth cohort study.International journal of epidemiology · 2016Article
- Socioeconomic conditions across life related to multiple measures of the endocrine system in older adults: Longitudinal findings from a British birth cohort study.Social science & medicine (1982) · 2015Article
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe medical needs of older people are growing because the proportion of the older population is increasing and disease boundaries are widening. This study describes the distribution and clustering of 15 common clinical disorders requiring medical treatment or supervision in a representative British cohort approaching retirement, and how health tracked across adulthood. METHODS AND
findingsThe data come from a cohort of 2661 men and women, 84% of the target sample, followed since birth in England, Scotland and Wales in 1946, and assessed at 60-64 years for: cardio and cerebro-vascular disease, hypertension, raised cholesterol, renal impairment, diabetes, obesity, hypothyroidism, hyperthyroidism, anaemia, respiratory disease, liver disease, psychiatric problems, cancers, atrial fibrillation on ECG and osteoporosis. We calculated the proportions disorder-free, with one or more disorders, and the level of undiagnosed disorders; and how these disorders cluster into latent classes and relate to health assessed at 36 years. Participants had, on average, two disorders (range 0-9); only 15% were disorder-free. The commonest disorders were hypertension (54.3%, 95% CI 51.8%-56.7%), obesity (31.1%, 28.8%-33.5%), raised cholesterol (25.6%, 23.1-28.26%), and diabetes or impaired fasting glucose (25.0%, 22.6-27.5%). A cluster of one in five individuals had a high probability of cardio-metabolic disorders and were twice as likely than others to have been in the poorest health at 36 years. The main limitations are that the native born sample is entirely white, and a combination of clinical assessments and self reports were used.
conclusionsMost British people reaching retirement already have clinical disorders requiring medical supervision. Widening disease definitions and the move from a disease-based to a risk-based medical model will increase pressure on health services. The promotion of healthy ageing should start earlier in life and consider the individual's ability to adapt to and self manage changes in health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.