ArticlePloS one2012
Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.Cytokine · 2016Trial
- Maturation of innate responses to mycobacteria over the first nine months of life.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Molecular Determinants of the Early Life Immune Response to COVID-19 Infection and Immunization.Vaccines · 2023Review
- Maternal imprinting and determinants of neonates' immune function in the SEPAGES mother-child cohort.Frontiers in immunology · 2023Article
- Associations between salivary cytokines and oral health, age, and sex in healthy children.Scientific reports · 2022Article
- Article
- Vaccine-Induced CD8Frontiers in immunology · 2020Review
- Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children.Frontiers in immunology · 2019Article
- Cytokine profiling in healthy children shows association of age with cytokine concentrations.Scientific reports · 2017Article
- Lack of broad functional differences in immunity in fully vaccinated vs. unvaccinated children.Pediatric research · 2017Article
- Microbiota Influences Vaccine and Mucosal Adjuvant Efficacy.Immune network · 2017Review
- Postnatal Innate Immune Development: From Birth to Adulthood.Frontiers in immunology · 2017Review
- Influence of Age and Other Factors on Cytokine Expression Profiles in Healthy Children-A Systematic Review.Frontiers in pediatrics · 2017Article
- Increasing JAK/STAT Signaling Function of Infant CD4Frontiers in pediatrics · 2017Article
- A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity.Frontiers in immunology · 2016Article
- Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Ontogeny of early life immunity.Trends in immunology · 2014Review
- Altered innate immune development in HIV-exposed uninfected infants.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Pattern recognition receptor-mediated cytokine response in infants across 4 continents.The Journal of allergy and clinical immunology · 2014Article
- Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
The first year of life represents a time of marked susceptibility to infections; this is particularly true for regions in sub-Saharan Africa. As innate immunity directs the adaptive immune response, the observed increased risk for infection as well as a suboptimal response to vaccination in early life may be due to less effective innate immune function. In this study, we followed a longitudinal cohort of infants born and raised in South Africa over the first year of life, employing the most comprehensive analysis of innate immune response to stimulation published to date. Our findings reveal rapid changes in innate immune development over the first year of life. This is the first report depicting dramatic differences in innate immune ontogeny between different populations in the world, with important implications for global vaccination strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.