Evidence map›Paper›PMID 23028596›Full record

Trial reportPloS one2012

Effects of pre-meal drinks with protein and amino acids on glycemic and metabolic responses at a subsequent composite meal.

Ulrika J Gunnerud, Cornelia Heinzle, Jens J Holst, Elin M Östman, Inger M E Björck

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01586780 (Effects of Pre-meal Drinks With Protein and Amino Acids on Glycemic and Metabolic Responses at a Subsequent Composite Meal), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01586780 nacompletednot on this map

Effects of Pre-meal Drinks With Protein and Amino Acids on Glycemic and Metabolic Responses at a Subsequent Composite Meal

TypeinterventionalSponsorLund UniversityRan2009 to 2009Enrolled14ConditionsDiabetes Mellitus, Type 2, Satiety ResponseArmsProtein drink, Reference meal
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ulrika J GunnerudDepartment of Applied Nutrition and Food Chemistry, Lund University, Lund, Sweden. ulrika.gunnerud@appliednutrition.lth.se
Cornelia Heinzle
Jens J Holst
Elin M Östman
Inger M E Björck

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhey proteins have insulinogenic properties and the effect appears to originate from a specific postprandial plasma amino acid pattern. The insulinogenic effect can be mimicked by a specific mixture of the five amino acids iso, leu, lys, thr and val.

objectiveThe objective was to evaluate the efficacy of pre-meal boluses of whey or soy protein with or without added amino acids on glycaemia, insulinemia as well as on plasma responses of incretins and amino acids at a subsequent composite meal. Additionally, plasma ghrelin and subjective appetite responses were studied.

designIn randomized order, fourteen healthy volunteers were served a standardized composite ham sandwich meal with either water provided (250 ml) during the time course of the meal, or different pre-meal protein drinks (PMPD) (100 ml provided as a bolus) with additional water (150 ml) served to the meal. The PMPDs contained 9 g protein and were based on either whey or soy protein isolates, with or without addition of the five amino acids (iso, leu, lys, thr and val) or the five amino acids + arg.

resultsAll PMPD meals significantly reduced incremental area for plasma glucose response (iAUC) during the first 60 min. All whey based PMPD meals displayed lower glycemic indices compared to the reference meal. There were no significant differences for the insulinemic indices. The early insulin response (iAUC 0-15 min) correlated positively to plasma amino acids, GIP and GLP-1 as well as to the glycemic profile. Additionally, inverse correlations were found between insulin iAUC 0-15 min and the glucose peak.

conclusionThe data suggests that a pre-meal drink containing specific proteins/amino acids significantly reduces postprandial glycemia following a composite meal, in absence of elevated insulinemic excursions. An early phase insulinemic response induced by plasma amino acids and incretins appears to mediate the effect.

trial registrationClinicalTrials.gov NCT01586780<NCT01586780>

Indexed as

MealsAdultAmino AcidsBlood GlucoseFemaleGastric Inhibitory PolypeptideGlucagon-Like Peptide 1HumansInsulinMaleMilk ProteinsSoybean ProteinsWhey ProteinsYoung AdultAmino AcidsBlood GlucoseGastric Inhibitory PolypeptideGlucagon-Like Peptide 1InsulinMilk ProteinsSoybean ProteinsWhey Proteins

Identifiers

PMID23028596
PMCPMC3446992

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.