ArticlePloS one2012
Killer immunoglobulin-like receptor (KIR) and HLA genotypes affect the outcome of allogeneic kidney transplantation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Orchestrating the Impact of KIR/HLA Interactions on Kidney Transplant.International journal of molecular sciences · 2024Article
- Article
- Killer Cell Immunoglobulin-like Receptors (KIR) and Human Leucocyte Antigen C (HLA-C) Increase the Risk of Long-Term Chronic Liver Graft Rejection.International journal of molecular sciences · 2022Article
- High-resolution human KIR genotyping.Immunogenetics · 2022Review
- Evaluation of telomeric KIR genes and their association with CMV infection in kidney transplant recipients.Immunogenetics · 2022Article
- Article
- Applying genomics in heart transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2018Review
- Article
- Genetic (KIR, HLA-C) and Some Clinical Parameters Influencing the Level of Liver Enzymes and Early Virologic Response in Patients with Chronic Hepatitis C.Archivum immunologiae et therapiae experimentalis · 2016Article
- KIR2DS5 in the presence of HLA-C C2 protects against endometriosis.Immunogenetics · 2015Article
- Investigation of deletion of 22pb in KIR2DS4 gene in a population of southern Brazil.Journal of clinical laboratory analysis · 2014Article
- Presence of the full-length KIR2DS4 gene reduces the chance of rheumatoid arthritis patients to respond to methotrexate treatment.BMC musculoskeletal disorders · 2014Article
- Impact of killer immunoglobulin-like receptor-human leukocyte antigens ligand incompatibility among renal transplantation.Indian journal of nephrologyArticle
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Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecipient NK cells may detect the lack of recipient's (i.e., self) HLA antigens on donor renal tissue by means of their killer cell immunoglobulin-like receptors (KIRs). KIR genes are differently distributed in individuals, possibly contributing to differences in response to allogeneic graft. METHODOLOGY/PRINCIPAL
findingsWe compared frequencies of 10 KIR genes by PCR-SSP in 93 kidney graft recipients rejecting allogeneic renal transplants with those in 190 recipients accepting grafts and 690 healthy control individuals. HLA matching results were drawn from medical records. We observed associations of both a full-length KIR2DS4 gene and its variant with 22-bp deletion with kidney graft rejection. This effect was modulated by the HLA-B,-DR matching, particularly in recipients who did not have glomerulonephritis but had both forms of KIR2DS4 gene. In contrast, in recipients with glomerulonephritis, HLA compatibility seemed to be much less important for graft rejection than the presence of KIR2DS4 gene. Simultaneous presence of both KIR2DS4 variants strongly increased the probability of rejection. Interestingly, KIR2DS5 seemed to protect the graft in the presence of KIR2DS4fl but in the absence of KIR2DS4del. CONCLUSIONS/SIGNIFICANCE: Our results suggest a protective role of KIR2DS5 in graft rejection and an association of KIR2DS4 with kidney rejection, particularly in recipients with glomerulonephritis.
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