SynthesisPloS one2012
Excess body mass index and risk of liver cancer: a nonlinear dose-response meta-analysis of prospective studies.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- AGA Clinical Practice Update on Bariatric Surgery in Cirrhosis: Expert Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Guideline
- Obesity and the risk of primary liver cancer: A systematic review and meta-analysis.Clinical and molecular hepatology · 2021Pooled it
- Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Obesity and cancer: the role of vitamin D.BMC cancer · 2014Pooled it
- Large cohort studies assessing sex-specific associations between anthropometric indices and liver cancer death.JHEP reports : innovation in hepatology · 2026Article
- Liver Cancer Mortality Rates in Peru: Trend Analysis from 2003 to 2017.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Trends in the burden of most common obesity-related cancers in 16 Southern Africa development community countries, 1990-2019. Findings from the global burden of disease study.Obesity science & practice · 2024Article
- The impact of body mass index on short-term and long-term surgical outcomes of laparoscopic hepatectomy in liver carcinoma patients: a retrospective study.World journal of surgical oncology · 2022Article
- KETOgenic diet therapy in patients with HEPatocellular adenoma: study protocol of a matched interventional cohort study.BMJ open · 2022Article
- Epidemiological link between obesity, type 2 diabetes mellitus and cancer.World journal of methodology · 2021Review
- The Role of IGF/IGF-1R Signaling in Hepatocellular Carcinomas: Stemness-Related Properties and Drug Resistance.International journal of molecular sciences · 2021Review
- Waist Circumference and Risk of Liver Cancer: A Systematic Review and Meta-Analysis of over 2 Million Cohort Study Participants.Liver cancer · 2020Review
- Meta-analysis reveals gender difference in the association of liver cancer incidence and excess BMI.Oncotarget · 2017Article
- Proportion of cancer in a Middle eastern country attributable to established risk factors.BMC cancer · 2017Article
- A case of liver hemangioma with markedly reduced tumor size after metformin treatment: a case report.Clinical journal of gastroenterology · 2017Article
- The impact of body mass index on short-term surgical outcomes after laparoscopic hepatectomy, a retrospective study.BMC anesthesiology · 2016Article
- Obesity, diabetes, serum glucose, and risk of primary liver cancer by birth cohort, race/ethnicity, and sex: Multiphasic health checkup study.Cancer epidemiology · 2016Article
- Association of serum α-tocopherol, β-carotene, and retinol with liver cancer incidence and chronic liver disease mortality.British journal of cancer · 2014Article
- Chemopreventive strategies in hepatocellular carcinoma.Nature reviews. Gastroenterology & hepatology · 2014Review
- Hepatocellular Carcinoma: Etiology and Current and Future Drugs.Journal of clinical and experimental hepatologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExcess body weight measured as body mass index (BMI) has a positive association with risk of common cancers. However, previous meta-analyses related to BMI and liver cancer had inconsistent results. The purpose of the current study is to establish a nonlinear dose-response relationship between BMI and incidence risk of liver cancer.
methodsA systematic literature search for relevant articles published from 1966 to November 2011 was conducted in PUBMED and EMBASE digital databases. Additional articles were manually searched by using the reference lists of identified papers. Restricted cubic splines and generalized least-squares regression methods were used to model a potential curvilinear relationship and to make a dose-response meta-analysis. Stratified analysis, sensitivity analysis and assessment of bias were performed in our meta-analysis.
results8 articles including 1,779,471 cohort individuals were brought into meta-analysis. A non-linear dose-response association between BMI and risk of liver cancer was visually significant (P for nonlinearity<0.001), besides, the point value of BMI also enhanced the results quantitatively, where relative risks were 1.02 (95%CI = 1.02-1.03), 1.35 (95%CI = 1.24-1.47) and 2.22-fold (95%CI = 1.74-2.83) when BMI was at the point of 25, 30 and 35 kg/m(2) compared with reference (the median value of the lowest category), respectively. The ethnicity of the population was found as the main source of heterogeneity. In subsequent stratified analysis, no evidence of heterogeneity was showed in Asian and White populations (P for heterogeneity>0.1), and all value of BMI still presented significantly increased risk of cancer.
conclusionsThe findings from meta-analysis provided that excess BMI had significant increased association with risk of liver cancer, although the biological mechanisms underlying the obesity-cancer link still need to be clarified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.