ArticlePloS one2012
Aqueous cytokine changes associated with Posner-Schlossman syndrome with and without human cytomegalovirus.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Risk Factors for Anti-Glaucoma Surgery in Posner-Schlossman Syndrome Patients: an 8-Year Retrospective Study.International journal of medical sciences · 2026Article
- Cytokines in patients with Posner-Schlossman syndrome.Frontiers in immunology · 2026Article
- One-year outcomes of trabeculectomy with mitomycin C in secondary glaucoma due to posner-schlossman syndrome.Scientific reports · 2025Article
- Roles played by IL-8 in altering dynamics of trabecular meshwork cells after human cytomegalovirus infection.Frontiers in cellular and infection microbiology · 2025Article
- Quantification of anterior scleral thickness in Posner-Schlossman syndrome.SAGE open medicine · 2025Article
- Cytokine analysis of aqueous humor in patients with cytomegalovirus corneal endotheliitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Quantification of Iris Atrophy by Swept-Source Optical Coherence Tomography in Posner-Schlossman Syndrome.Journal of clinical medicine · 2022Article
- Clinical characteristics of virus-related uveitic secondary glaucoma: focus on cytomegalovirus and varicella zoster virus.BMC ophthalmology · 2022Article
- Morphology of the Trabecular Meshwork and Schlemm's Canal in Posner-Schlossman Syndrome.Investigative ophthalmology & visual science · 2022Article
- Analysis of risk factors associated with secondary open-angle glaucoma in Posner-Schlossman syndrome: A retrospective case-control study.Frontiers in medicine · 2022Article
- The Value of the Antibody Detection in the Diagnosis of Ocular Toxocariasis and the Aqueous Cytokine Profile Associated With the Condition.Frontiers in medicine · 2022Article
- Long-term prognosis for glaucoma in patients with Posner-Schlossman syndrome.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Structure-Function Relationship and Vision-Related Quality of Life in Glaucoma Secondary to Anterior Uveitis: Comparison with Open Angle Glaucoma.Journal of clinical medicine · 2021Article
- Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells.Scientific reports · 2021Article
- Effects of ROCK Inhibitors on Apoptosis of Corneal Endothelial Cells in CMV-Positive Posner-Schlossman Syndrome Patients.Investigative ophthalmology & visual science · 2020Article
- Involvement of autotaxin in the pathophysiology of elevated intraocular pressure in Posner-Schlossman syndrome.Scientific reports · 2020Article
- Observational
- High interleukin-8 level in aqueous humor is associated with poor prognosis in eyes with open angle glaucoma and neovascular glaucoma.Scientific reports · 2018Article
- Different composition of intraocular immune mediators in Posner-Schlossman-Syndrome and Fuchs' Uveitis.PloS one · 2018Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the differences in aqueous cytokines in Posner-Schlossman Syndrome (PSS) patients with and without human cytomegalovirus (CMV) DNA in the aqueous humor.
methodsThis is a prospective study. Fifty-three uveitis patients with clinical signs of PSS were enrolled and aqueous humor samples were collected. Fourteen PSS patients were positive of CMV DNA in the aqueous by polymerase chain reaction (PCR) analysis. These eyes were negative of common ocular pathogens such as herpes simplex virus, varicella-zoster virus, rubella virus and toxoplasma. Twenty-five otherwise healthy cataract patients were enrolled as controls. Cytokine concentration was measured by a magnetic color-bead-based multiplex assay and analyzed using statistical and classification approaches.
resultsThe average age of 53 PSS patients was 48.74±13.43 years (yrs) (mean ± standard deviation) and 66.3±15.0 yrs for the controls. The median CMV viral DNA copy number was 26000/mL aqueous (range 1400 to 85000 copies/mL) in 14 CMV positive patients as determined by quantitative PCR. PSS aqueous had significantly higher Interleukin (IL)-8 (CXCL8), monocyte chemotactic protein-1 (CCL2), macrophage inhibitory protein 1-β (CCL4), granulocyte colony-stimulating factor (GCSF) and transforming growth factor-β (TGF-β) levels than controls after adjusted by age and gender. IL-2, IL-12, tumor necrosis factor-α (TNF-α) and interferon-α (IFN-α) levels were significantly lower in PSS aqueous than controls. No difference between CMV positive PSS and CMV negative PSS aqueous was observed. Over 97% of PSS samples were distinguished from controls by elevated CXCL10 (>500 ng/mL), CXCL8 (>30 ng/mL) and CCL2 (>60 ng/mL) levels.
conclusionPSS eyes were characterized by elevated aqueous chemokine concentration. The presence of CMV viral DNA was not associated with significant change of the type of cytokine expression in PSS patients.
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