ArticlePloS one2012
Comparison of intact Arabidopsis thaliana leaf transcript profiles during treatment with inhibitors of mitochondrial electron transport and TCA cycle.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Alternative oxidase (AOX) 1a and 1d limit proline-induced oxidative stress and aid salinity recovery in Arabidopsis.Plant physiology · 2022Article
- Altering the balance between AOX1A and NDB2 expression affects a common set of transcripts in Arabidopsis.Frontiers in plant science · 2022Article
- CarrotPlants (Basel, Switzerland) · 2021Article
- ACONITASE 3 is part of theANAC017 transcription factor-dependent mitochondrial dysfunction response.Plant physiology · 2021Article
- Mitochondrial Stress Induces Plant Resistance Through Chromatin Changes.Frontiers in plant science · 2021Article
- The transcription factor ANAC017 is a key regulator of mitochondrial proteotoxic stress responses in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.Scientific reports · 2020Article
- Matrix Redox Physiology Governs the Regulation of Plant Mitochondrial Metabolism through Posttranslational Protein Modifications.The Plant cell · 2020Review
- DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis.Journal of experimental botany · 2019Article
- Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants.Plant physiology · 2018Review
- The Transcription Factor MYB29 Is a Regulator ofPlant physiology · 2017Article
- DEWAX Transcription Factor Is Involved in Resistance toFrontiers in plant science · 2017Article
- Plant-Specific Preprotein and Amino Acid Transporter Proteins Are Required for tRNA Import into Mitochondria.Plant physiology · 2016Article
- Decreasing electron flux through the cytochrome and/or alternative respiratory pathways triggers common and distinct cellular responses dependent on growth conditions.Plant physiology · 2015Article
- The importance of cardiolipin synthase for mitochondrial ultrastructure, respiratory function, plant development, and stress responses in Arabidopsis.The Plant cell · 2013Article
- Mitochondrial energy and redox signaling in plants.Antioxidants & redox signaling · 2013Review
- Alternative oxidase: a mitochondrial respiratory pathway to maintain metabolic and signaling homeostasis during abiotic and biotic stress in plants.International journal of molecular sciences · 2013Review
- Reactive oxygen species mediate growth and death in submerged plants.Frontiers in plant science · 2013Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant mitochondria signal to the nucleus leading to altered transcription of nuclear genes by a process called mitochondrial retrograde regulation (MRR). MRR is implicated in metabolic homeostasis and responses to stress conditions. Mitochondrial reactive oxygen species (mtROS) are a MRR signaling component, but whether all MRR requires ROS is not established. Inhibition of the cytochrome respiratory pathway by antimycin A (AA) or the TCA cycle by monofluoroacetate (MFA), each of which initiates MRR, can increase ROS production in some plant cells. We found that for AA and MFA applied to leaves of soil-grown Arabidopsis thaliana plants, ROS production increased with AA, but not with MFA, allowing comparison of transcript profiles under different ROS conditions during MRR. Variation in transcript accumulation over time for eight nuclear encoded mitochondrial protein genes suggested operation of both common and distinct signaling pathways between the two treatments. Consequences of mitochondrial perturbations for the whole transcriptome were examined by microarray analyses. Expression of 1316 and 606 genes was altered by AA and MFA, respectively. A subset of genes was similarly affected by both treatments, including genes encoding photosynthesis-related proteins. MFA treatment resulted in more down-regulation. Functional gene category (MapMan) and cluster analyses showed that genes with expression levels affected by perturbation from AA or MFA inhibition were most similarly affected by biotic stresses such as pathogens. Overall, the data provide further evidence for the presence of mtROS-independent MRR signaling, and support the proposed involvement of MRR and mitochondrial function in plant responses to biotic stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.