SynthesisPloS one2012
Effects of psychological stress on innate immunity and metabolism in humans: a systematic analysis.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Article
- Unintended Consequences of COVID-19 Non-Pharmaceutical Interventions (NPIs) for Population Health and Health Inequalities.International journal of environmental research and public health · 2023Review
- Controllable and Uncontrollable Stress Differentially Impact Fear Conditioned Alterations in Sleep and Neuroimmune Signaling in Mice.Life (Basel, Switzerland) · 2022Article
- Evaluation of the Influence of Biological Factors during the Course of Treatment in Patients with Ovarian Cancer.International journal of environmental research and public health · 2022Article
- Effects of Probiotics at the Interface of Metabolism and Immunity to Prevent Colorectal Cancer-Associated Gut Inflammation: A Systematic Network and Meta-Analysis With Molecular Docking Studies.Frontiers in microbiology · 2022Article
- Article
- Systematic Network and Meta-analysis on the Antiviral Mechanisms of Probiotics: A Preventive and Treatment Strategy to Mitigate SARS-CoV-2 Infection.Probiotics and antimicrobial proteins · 2021Article
- Influence of Psychological Distress in Patients with Hypoallergenic Total Knee Arthroplasty. Treatment Algorithm for Patients with Metal Allergy and Knee Osteoarthritis.International journal of environmental research and public health · 2021Article
- The Case for Therapeutic Massage as an Adjuvant in Hospitalized COVID-19 Patients.International journal of therapeutic massage & bodywork · 2021Article
- Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis.Frontiers in cell and developmental biology · 2021Article
- Macrophage plays important role in cortisol and serotonin induced adipogenesis in vitro.In vitro cellular & developmental biology. Animal · 2020Article
- Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells.Communications biology · 2020Article
- BETA ENDORPHINS - HOLISTIC THERAPEUTIC APPROACH TO CANCER.Annals of Ibadan postgraduate medicine · 2019Article
- Blood plasma metabolic profiling of pregnant women with antenatal depressive symptoms.Translational psychiatry · 2019Article
- Surveying, shoring, strengthening: rebuilding medical morale from its foundations .Clinical medicine (London, England) · 2019Review
- Aggravated mucosal and immune damage in a mouse model of ulcerative colitis with stress.Experimental and therapeutic medicine · 2019Article
- Microarray‑based screening of differentially expressed genes in glucocorticoid‑induced avascular necrosis.Molecular medicine reports · 2017Article
- Article
- Perceived Stress in Black and Latino Male Firefighters: Associations with Risk and Protective Factors.Ethnicity & disease · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress is perhaps easiest to conceptualize as a process which allows an organism to accommodate for the demands of its environment such that it can adapt to the prevailing set of conditions. Psychological stress is an important component with the potential to affect physiology adversely as has become evident from various studies in the area. Although these studies have established numerous effects of psychological stress on physiology, a global strategy for the correlation of these effects has yet to begin. Our comparative and systematic analysis of the published literature has unraveled certain interesting molecular mechanisms as clues to account for some of the observed effects of psychological stress on human physiology. In this study, we attempt to understand initial phase of the physiological response to psychological stress by analyzing interactions between innate immunity and metabolism at systems level by analyzing the data available in the literature. In light of our gene association-networks and enrichment analysis we have identified candidate genes and molecular systems which might have some associative role in affecting psychological stress response system or even producing some of the observed terminal effects (such as the associated physiological disorders). In addition to the already accepted role of psychological stress as a perturbation that can disrupt physiological homeostasis, we speculate that it is potentially capable of causing deviation of certain biological processes from their basal level activity after which they can return back to their basal tones once the effects of stress diminish. Based on the derived inferences of our comparative analysis, we have proposed a probabilistic mechanism for how psychological stress could affect physiology such that these adaptive deviations are sometimes not able to bounce back to their original basal tones, and thus increase physiological susceptibility to metabolic and immune imbalance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.