ArticlePLoS genetics2012
Coevolution within and between regulatory loci can preserve promoter function despite evolutionary rate acceleration.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Intergeneric chromosomal transfer in yeast results in improved phenotypes and widespread transcriptional responses.Nature communications · 2026Article
- Biophysical constraints on mRNA decay rates shape macroevolutionary divergence in steady-state abundances.bioRxiv : the preprint server for biology · 2025Article
- Lineage-resolved analysis of embryonic gene expression evolution inScience (New York, N.Y.) · 2025Article
- Genomic Analysis of Indel and SV Reveals Functional and Adaptive Signatures in Hubei Indigenous Cattle Breeds.Animals : an open access journal from MDPI · 2025Article
- Mating system and speciation I: Accumulation of genetic incompatibilities in allopatry.PLoS genetics · 2022Article
- On the impermanence of species: The collapse of genetic incompatibilities in hybridizing populations.Evolution; international journal of organic evolution · 2022Article
- The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements.Development, growth & differentiation · 2021Article
- Widespread misregulation of inter-species hybrid transcriptomes due to sex-specific and sex-chromosome regulatory evolution.PLoS genetics · 2021Article
- Tightly linked antagonistic-effect loci underlie polygenic phenotypic variation inEvolution letters · 2019Article
- Molecular evolution across developmental time reveals rapid divergence in early embryogenesis.Evolution letters · 2019Article
- Promoter conservation in HDACs points to functional implications.BMC genomics · 2019Article
- From "the Worm" to "the Worms" and Back Again: The Evolutionary Developmental Biology of Nematodes.Genetics · 2018Review
- Sequence and functional characterization of MIRNA164 promoters from Brassica shows copy number dependent regulatory diversification among homeologs.Functional & integrative genomics · 2018Article
- Article
- Gene Regulation and Speciation.Trends in genetics : TIG · 2017Review
- Evolution of New cis-Regulatory Motifs Required for Cell-Specific Gene Expression in Caenorhabditis.PLoS genetics · 2016Article
- Divergent MLS1 Promoters Lie on a Fitness Plateau for Gene Expression.Molecular biology and evolution · 2016Article
- When natural selection gives gene function the cold shoulder.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Article
- A 190 base pair, TGF-β responsive tooth and fin enhancer is required for stickleback Bmp6 expression.Developmental biology · 2015Article
Corrections and comments
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3 authors.
Funding
Abstract
Phenotypes that appear to be conserved could be maintained not only by strong purifying selection on the underlying genetic systems, but also by stabilizing selection acting via compensatory mutations with balanced effects. Such coevolution has been invoked to explain experimental results, but has rarely been the focus of study. Conserved expression driven by the unc-47 promoters of Caenorhabditis elegans and C. briggsae persists despite divergence within a cis-regulatory element and between this element and the trans-regulatory environment. Compensatory changes in cis and trans are revealed when these promoters are used to drive expression in the other species. Functional changes in the C. briggsae promoter, which has experienced accelerated sequence evolution, did not lead to alteration of gene expression in its endogenous environment. Coevolution among promoter elements suggests that complex epistatic interactions within cis-regulatory elements may facilitate their divergence. Our results offer a detailed picture of regulatory evolution in which subtle, lineage-specific, and compensatory modifications of interacting cis and trans regulators together maintain conserved gene expression patterns.
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