ArticlePLoS genetics2012
Determinants of human adipose tissue gene expression: impact of diet, sex, metabolic status, and cis genetic regulation.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Association of Lifestyle-Induced Weight Loss With Gene Expression in Subcutaneous Adipose Tissue in Metabolic Syndrome.Journal of diabetes · 2025Trial
- Integrative phenotyping of glycemic responders upon clinical weight loss using multi-omics.Scientific reports · 2020Trial
- Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance.PloS one · 2016Trial
- Trial
- Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass.PLoS biology · 2013Trial
- Fetuin B Is Related to Cytokine/Chemokine and Insulin Signaling in Adipose Tissue and Plasma in Humans.The Journal of clinical endocrinology and metabolism · 2025Article
- Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1.International journal of obesity (2005) · 2024Article
- DNA methylation and waist-to-hip ratio: an epigenome-wide association study in Chinese monozygotic twins.Journal of endocrinological investigation · 2022Article
- Article
- Biological Determinants of Metabolic Syndrome in Visceral and Subcutaneous Adipose Tissue from Severely Obese Women.International journal of molecular sciences · 2022Article
- Effects of low-calorie and different weight-maintenance diets on IgG glycome composition.Frontiers in immunology · 2022Article
- Human adipose and skeletal muscle tissue DNA, RNA, and protein content.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales.Life (Basel, Switzerland) · 2021Review
- The association between vitamin D receptor polymorphisms and tissue-specific insulin resistance in human obesity.International journal of obesity (2005) · 2021Article
- Metabolite Changes After Metabolic Surgery - Associations to Parameters Reflecting Glucose Homeostasis and Lipid Levels.Frontiers in endocrinology · 2021Observational
- Short-Term Caloric Restriction Attenuates Obesity-Induced Pro-Inflammatory Response in Male Rhesus Macaques.Nutrients · 2020Article
- FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression.International journal of obesity (2005) · 2019Article
- Conservation, acquisition, and functional impact of sex-biased gene expression in mammals.Science (New York, N.Y.) · 2019Article
- Resistance to visceral obesity is associated with increased locomotion in mice expressing an endothelial cell-specific fibroblast growth factor 1 transgene.Physiological reports · 2019Article
- Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans.The Journal of clinical endocrinology and metabolism · 2018Article
Corrections and comments
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Authors and funding
16 authors at 11 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weight control diets favorably affect parameters of the metabolic syndrome and delay the onset of diabetic complications. The adaptations occurring in adipose tissue (AT) are likely to have a profound impact on the whole body response as AT is a key target of dietary intervention. Identification of environmental and individual factors controlling AT adaptation is therefore essential. Here, expression of 271 transcripts, selected for regulation according to obesity and weight changes, was determined in 515 individuals before, after 8-week low-calorie diet-induced weight loss, and after 26-week ad libitum weight maintenance diets. For 175 genes, opposite regulation was observed during calorie restriction and weight maintenance phases, independently of variations in body weight. Metabolism and immunity genes showed inverse profiles. During the dietary intervention, network-based analyses revealed strong interconnection between expression of genes involved in de novo lipogenesis and components of the metabolic syndrome. Sex had a marked influence on AT expression of 88 transcripts, which persisted during the entire dietary intervention and after control for fat mass. In women, the influence of body mass index on expression of a subset of genes persisted during the dietary intervention. Twenty-two genes revealed a metabolic syndrome signature common to men and women. Genetic control of AT gene expression by cis signals was observed for 46 genes. Dietary intervention, sex, and cis genetic variants independently controlled AT gene expression. These analyses help understanding the relative importance of environmental and individual factors that control the expression of human AT genes and therefore may foster strategies aimed at improving AT function in metabolic diseases.
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