ArticlePLoS genetics2012
Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Heterochromatin protein 1 (HP1) dysfunction drives male-biased sex ratio in Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae) via paternal genome elimination during mitosis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Article
- HP1-Mediated Silencing of theJournal of developmental biology · 2025Article
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- Emerging Roles for Chromo Domain Proteins in Genome Organization and Cell Fate inFrontiers in cell and developmental biology · 2020Review
- Chromatin Compaction by Small RNAs and the Nuclear RNAi Machinery in C. elegans.Scientific reports · 2019Article
- LRIF1 interacts with HP1α to coordinate accurate chromosome segregation during mitosis.Journal of molecular cell biology · 2018Article
- Repressive Chromatin inGenetics · 2018Review
- Article
- Germline-specific H1 variants: the "sexy" linker histones.Chromosoma · 2016Review
- Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man.EMBO reports · 2016Review
- Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3.Scientific reports · 2015Article
- Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.Genome research · 2015Article
- The spatiotemporal dynamics of chromatin protein HP1α is essential for accurate chromosome segregation during cell division.The Journal of biological chemistry · 2014Article
- HP1 knockdown is associated with abnormal condensation of almost all chromatin types in a grasshopper (Eyprepocnemis plorans).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Article
- Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.BMC developmental biology · 2014Article
- HP1a: a structural chromosomal protein regulating transcription.Trends in genetics : TIG · 2014Review
- Regulatory roles of RNA binding proteins in the nervous system of C. elegans.Frontiers in molecular neuroscience · 2014Review
- Conserved nutrient sensor O-GlcNAc transferase is integral to C. elegans pathogen-specific immunity.PloS one · 2014Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elucidation of the biological role of linker histone (H1) and heterochromatin protein 1 (HP1) in mammals has been difficult owing to the existence of a least 11 distinct H1 and three HP1 subtypes in mice. Caenorhabditis elegans possesses two HP1 homologues (HPL-1 and HPL-2) and eight H1 variants. Remarkably, one of eight H1 variants, HIS-24, is important for C. elegans development. Therefore we decided to analyse in parallel the transcriptional profiles of HIS-24, HPL-1/-2 deficient animals, and their phenotype, since hpl-1, hpl-2, and his-24 deficient nematodes are viable. Global transcriptional analysis of the double and triple mutants revealed that HPL proteins and HIS-24 play gene-specific roles, rather than a general repressive function. We showed that HIS-24 acts synergistically with HPL to allow normal reproduction, somatic gonad development, and vulval cell fate decision. Furthermore, the hpl-2; his-24 double mutant animals displayed abnormal development of the male tail and ectopic expression of C. elegans HOM-C/Hox genes (egl-5 and mab-5), which are involved in the developmental patterning of male mating structures. We found that HPL-2 and the methylated form of HIS-24 specifically interact with the histone H3 K27 region in the trimethylated state, and HIS-24 associates with the egl-5 and mab-5 genes. Our results establish the interplay between HPL-1/-2 and HIS-24 proteins in the regulation of positional identity in C. elegans males.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.