Evidence map›Paper›PMID 23028223›Full record

ArticleInternational journal of nanomedicine2012

A sandwich-type DNA electrochemical biosensor for hairpin-stem-loop structure based on multistep temperature-controlling method.

Guolin Hong, Yinhuan Liu, Wei Chen, Shaohuang Weng, Qicai Liu, Ailin Liu, Daoxin Zheng, Xinhua Lin

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances in airborne microorganisms detection using biosensors: A critical review.Frontiers of environmental science & engineering · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guolin HongDepartment of Laboratory Medicine, The Fuzhou Second Affiliated Hospital of Xiamen University, Fuzhou, China.
Yinhuan Liu
Wei Chen
Shaohuang Weng
Qicai Liu
Ailin Liu
Daoxin Zheng
Xinhua Lin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A highly sensitive and selective method for amplified electrochemical detection for hairpin-stem-loop structured target sequences was developed based on the temperature regulation of DNA hybrids on a sandwich-type electrochemical DNA sensor. Multistep hybridization was applied to promote the hybridization efficiency of each section of sandwich structure. The results showed that both multistep and temperature-controlling hybridization techniques were both especially made to fabricate the sensor for the tendency of internal hybridization of target gene sequences. This strategy provides significantly enhanced hybridization efficiency and sequence specificity of electrochemical detection.

Indexed as

MicroelectrodesBase SequenceBiosensing TechniquesConductometryDNAEquipment DesignEquipment Failure AnalysisInverted Repeat SequencesMolecular Sequence DataSequence Analysis, DNADNADNA hybridizationmultistep temperature-controllingsandwich-type biosensorstructured targettubercle bacillus

Identifiers

PMID23028223
PMCPMC3446862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.