ArticleThe Journal of cell biology2012
Differentiation-associated microRNAs antagonize the Rb-E2F pathway to restrict proliferation.
Article in The Journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
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- Coordination among frequent genetic variants imparts substance use susceptibility and pathogenesis.Frontiers in neuroscience · 2024Article
- Impact of fetal exposure to mycotoxins on longissimus muscle fiber hypertrophy and miRNA profile.BMC genomics · 2022Article
- miRNA transcriptome and myofiber characteristics of lamb skeletal muscle during hypertrophic growthFrontiers in genetics · 2022Article
- MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells.Scientific reports · 2021Article
- c-Myc inhibits myoblast differentiation and promotes myoblast proliferation and muscle fibre hypertrophy by regulating the expression of its target genes, miRNAs and lincRNAs.Cell death and differentiation · 2019Article
- Dual role for miR-34a in the control of early progenitor proliferation and commitment in the mammary gland and in breast cancer.Oncogene · 2019Article
- Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/β-catenin pathway.Cell death & disease · 2018Article
- A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder.Disease markers · 2018Article
- Differentially expressed miRNAs in hepatocellular carcinoma cells under hypoxic conditions are associated with transcription and phosphorylation.Oncology letters · 2018Article
- Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review).International journal of oncology · 2017Review
- A network-biology perspective of microRNA function and dysfunction in cancer.Nature reviews. Genetics · 2016Review
- The role of microRNAs in respiratory viral infection: friend or foe?Reviews in medical virology · 2016Review
- Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma.Cancer research · 2016Article
- Using miRNA-mRNA Interaction Analysis to Link Biologically Relevant miRNAs to Stem Cell Identity Testing for Next-Generation Culturing Development.Stem cells translational medicine · 2016Article
- The Landscape of microRNA Targeting in Prostate Cancer Defined by AGO-PAR-CLIP.Neoplasia (New York, N.Y.) · 2016Article
- Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells.Oncogene · 2016Article
- Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells.Physiological genomics · 2015Article
- Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells.The EMBO journal · 2015Article
- An intronic microRNA links Rb/E2F and EGFR signaling.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cancer-associated loss of microRNA (miRNA) expression leads to a proliferative advantage and aggressive behavior through largely unknown mechanisms. Here, we exploit a model system that recapitulates physiological terminal differentiation and its reversal upon oncogene expression to analyze coordinated mRNA/miRNA responses. The cell cycle reentry of myotubes, forced by the E1A oncogene, was associated with a pattern of mRNA/miRNA modulation that was largely reciprocal to that induced during the differentiation of myoblasts into myotubes. The E1A-induced mRNA response was preponderantly Retinoblastoma protein (Rb)-dependent. Conversely, the miRNA response was mostly Rb-independent and exerted through tissue-specific factors and Myc. A subset of these miRNAs (miR-1, miR-34, miR-22, miR-365, miR-29, miR-145, and Let-7) was shown to coordinately target Rb-dependent cell cycle and DNA replication mRNAs. Thus, a dual level of regulation-transcriptional regulation via Rb-E2F and posttranscriptional regulation via miRNAs-confers robustness to cell cycle control and provides a molecular basis to understand the role of miRNA subversion in cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.