ArticleThe Journal of biological chemistry2012
The redox-sensing transcriptional regulator RexT controls expression of thioredoxin A2 in the cyanobacterium Anabaena sp. strain PCC 7120.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 38 citations in OpenAlex.
- From photosynthetic electron flow to gene regulation: redox signal transduction in cyanobacteria.FEMS microbiology reviews · 2026Review
- Chlorophyllase fromACS bio & med chem Au · 2024Article
- Cold plasma pretreatment reinforces the lignocellulose-derived aldehyde inhibitors tolerance and bioethanol fermentability for Zymomonas mobilis.Biotechnology for biofuels and bioproducts · 2023Article
- The ArsH Protein Product of theAntioxidants (Basel, Switzerland) · 2022Article
- Exploring the Diversity of the Thioredoxin Systems in Cyanobacteria.Antioxidants (Basel, Switzerland) · 2022Review
- Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT.Communications biology · 2022Article
- Thioredoxin Dependent Changes in the Redox States of FurA fromAntioxidants (Basel, Switzerland) · 2021Article
- Plasmids encode niche-specific traits inMicrobial genomics · 2021Article
- Thioredoxin targets are regulated in heterocysts of cyanobacterium Anabaena sp. PCC 7120 in a light-independent manner.Journal of experimental botany · 2020Article
- Interaction of the GntR-family transcription factor Sll1961 with thioredoxin in the cyanobacterium Synechocystis sp. PCC 6803.Scientific reports · 2018Article
- Metallochaperones and metalloregulation in bacteria.Essays in biochemistry · 2017Review
- Corynebacterium glutamicum methionine sulfoxide reductase A uses both mycoredoxin and thioredoxin for regeneration and oxidative stress resistance.Applied and environmental microbiology · 2015Article
- The composition of the global and feature specific cyanobacterial core-genomes.Frontiers in microbiology · 2015Article
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2 authors at 1 institution in 1 country.
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Abstract
backgroundThioredoxins (Trxs) play a crucial role in the oxidative stress response.
resultsA redox-sensing transcriptional regulator, RexT, controls expression of TrxA2, and TrxA2 regulates the DNA binding activity of RexT.
conclusionThe RexT-TrxA2 regulatory system regulates gene expression in response to redox state. SIGNIFICANCE: This is the first report on a transcriptional regulator of the trx gene in cyanobacteria. Thioredoxins are ubiquitous proteins that catalyze thiol-disulfide redox reactions. They have a crucial role in the oxidative stress response as well as the redox regulation of metabolic enzymes. In cyanobacteria, little is known about the regulation of trx gene expression despite the importance of thioredoxins in cellular functions. In the present study, transcriptional regulation of the trx genes under oxidative stress conditions was investigated in the heterocystous cyanobacterium Anabaena sp. strain PCC 7120. When cells were exposed to H(2)O(2), only the trxA2 gene (all1866) of seven trx genes was induced. Disruption of the rexT gene (alr1867), encoding a transcriptional regulator of the ArsR family, resulted in increased expression of trxA2. RexT bound to the region downstream of the transcription initiation site of trxA2. The DNA binding activity of RexT was impaired by H(2)O(2) through the formation of an intramolecular disulfide bond, which induced expression of the trxA2 gene. The inactivated DNA binding activity of RexT was restored by reduced TrxA2. Hence, RexT is considered as a redox-sensing transcriptional repressor of trxA2. These results support the idea that the RexT-TrxA2 regulatory system is important for the oxidative stress response in this cyanobacterium.
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