ReviewThe Journal of physiology2012
Structural tuning and plasticity of the axon initial segment in auditory neurons.
Review in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Cortical control of chandelier cells in neural codes.Frontiers in cellular neuroscience · 2022Pooled it
- Diversity of axon initial segment geometry in the mouse hippocampus and its predicted influence on neuronal excitability.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Variation in the Involvement of Hippocampal Pyramidal Cell Subtypes in Spatial Learning Tasks.eNeuro · 2025Article
- Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants.Journal of computational neuroscience · 2025Article
- Article
- Motor learning changes the axon initial segment of the spinal motoneuron.The Journal of physiology · 2024Article
- A class-specific effect of dysmyelination on the excitability of hippocampal interneurons.eLife · 2023Article
- An adaptive behavioral control motif mediated by cortical axo-axonic inhibition.Nature neuroscience · 2023Article
- Article
- Structure and dynamics that specialize neurons for high-frequency coincidence detection in the barn owl nucleus laminaris.Biological cybernetics · 2023Article
- An adaptive behavioral control motif mediated by cortical axo-axonic inhibition.bioRxiv : the preprint server for biology · 2023Article
- The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- CDK5/p35-Dependent Microtubule Reorganization Contributes to Homeostatic Shortening of the Axon Initial Segment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference.Frontiers in synaptic neuroscience · 2022Review
- Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex.Nature communications · 2021Article
- Article
- Structural and Functional Refinement of the Axon Initial Segment in Avian Cochlear Nucleus during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome.Cell reports · 2020Article
- Robustness to Axon Initial Segment Variation Is Explained by Somatodendritic Excitability in Rat Substantia Nigra Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Maturation Dynamics of the Axon Initial Segment (AIS) of Newborn Dentate Granule Cells in Young Adult C57BL/6J Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The axon initial segment (AIS) that separates axonal and somato-dendritic compartments is a highly specialised neuronal structure enriched with voltage-gated Na(+) channels and functions as the site of spike initiation in neurons. The AIS was once thought to be uniform and static in structure, but has been found to be organised in a manner specific to the function of individual neurons and to exhibit plasticity with changes in synaptic inputs. Such structural specialisations are found in the avian auditory system. In the nucleus magnocellularis (NM), which is involved in a precise relay of timing information, the length of the AIS differs depending on sound frequency and increases with decreasing frequencies to accommodate frequency-specific variations in synaptic inputs. In the nucleus laminaris, which integrates the timing information from both NMs for sound localisation, the length and the location of the AIS vary depending on sound frequency: AISs are shorter and more remote for higher frequency. Furthermore, the AISs of NM neurons elongate to increase their excitability when synaptic inputs are removed by cochlea ablation, suggesting their contribution to the homeostatic control of neural activity. These structural tunings and plasticities of the AIS are thus indispensable for the function of the auditory circuits in both normal and pathological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.