ReviewThe Journal of physiology2012
Skeletal muscle vasodilatation during maximal exercise in health and disease.
Review in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Repeated-Sprint Training in Hypoxia on Sea-Level Performance: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Plasma Nucleotide Dynamics during Exercise and Recovery in Highly Trained Athletes and Recreationally Active Individuals.BioMed research international · 2018Trial
- Impaired training-induced adaptation of blood pressure in COPD patients: implication of the muscle capillary bed.International journal of chronic obstructive pulmonary disease · 2016Trial
- AKG/OXGR1 promotes skeletal muscle blood flow and metabolism by relaxing vascular smooth muscle.Life metabolism · 2022Article
- A Heart Rate Step Function Response Method for the Evaluation of Pulse Wave Velocity as a Predictor of Major Adverse Cardio-Vascular Events.Medicina (Kaunas, Lithuania) · 2022Article
- Article
- Passive leg movement-induced vasodilation and exercise-induced sympathetic vasoconstriction.Autonomic neuroscience : basic & clinical · 2022Article
- Intravoxel Incoherent Motion Magnetic Resonance Imaging in Skeletal Muscle: Review and Future Directions.Journal of magnetic resonance imaging : JMRI · 2022Review
- Central and Peripheral Oxygen Distribution in Two Different Modes of Interval Training.Metabolites · 2021Article
- SPECT/CT quantification of lower limb perfusion: The next frontier in radionuclide perfusion imaging?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Alterations in Exercise-Induced Plasma Adenosine Triphosphate Concentration in Highly Trained Athletes in a One-Year Training Cycle.Metabolites · 2019Article
- Contrast Enhanced Ultrasound Perfusion Imaging in Skeletal Muscle.Journal of cardiovascular imaging · 2019Review
- Vasodilatory function in human skeletal muscle feed arteries with advancing age: the role of adropin.The Journal of physiology · 2019Article
- Perfusion dynamics assessment with Power Doppler ultrasound in skeletal muscle during maximal and submaximal cycling exercise.European journal of applied physiology · 2018Article
- High-intensity interval training in hypoxia does not affect muscle HIF responses to acute hypoxia in humans.European journal of applied physiology · 2018Article
- Article
- Skeletal muscle contraction-induced vasodilation in the microcirculation.Journal of exercise rehabilitation · 2017Review
- Assessment of muscle function using hybrid PET/MRI: comparison ofEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Physiological Adaptations to Hypoxic vs. Normoxic Training during Intermittent Living High.Frontiers in physiology · 2017Article
- The mechanistic bases of the power-time relationship: muscle metabolic responses and relationships to muscle fibre type.The Journal of physiology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maximal exercise vasodilatation results from the balance between vasoconstricting and vasodilating signals combined with the vascular reactivity to these signals. During maximal exercise with a small muscle mass the skeletal muscle vascular bed is fully vasodilated. During maximal whole body exercise, however, vasodilatation is restrained by the sympathetic system. This is necessary to avoid hypotension since the maximal vascular conductance of the musculature exceeds the maximal pumping capacity of the heart. Endurance training and high-intensity intermittent knee extension training increase the capacity for maximal exercise vasodilatation by 20-30%, mainly due to an enhanced vasodilatory capacity, as maximal exercise perfusion pressure changes little with training. The increase in maximal exercise vascular conductance is to a large extent explained by skeletal muscle hypertrophy and vascular remodelling. The vasodilatory capacity during maximal exercise is reduced or blunted with ageing, as well as in chronic heart failure patients and chronically hypoxic humans; reduced vasodilatory responsiveness and increased sympathetic activity (and probably, altered sympatholysis) are potential mechanisms accounting for this effect. Pharmacological counteraction of the sympathetic restraint may result in lower perfusion pressure and reduced oxygen extraction by the exercising muscles. However, at the same time fast inhibition of the chemoreflex in maximally exercising humans may result in increased vasodilatation, further confirming a restraining role of the sympathetic nervous system on exercise-induced vasodilatation. This is likely to be critical for the maintenance of blood pressure in exercising patients with a limited heart pump capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.