ArticleThe Journal of physiology2013
Progressive limb ataxia following inferior olive lesions.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Multifaceted Mesodiencephalic Triangles: Insights into Hypertrophic Olivary Degeneration and Oculopalatal Tremor Pathophysiology.Cerebellum (London, England) · 2025Review
- Purkinje cell microzones mediate distinct kinematics of a single movement.Nature communications · 2023Article
- Article
- Control of Mammalian Locomotion by Somatosensory Feedback.Comprehensive Physiology · 2021Article
- Quantitative evaluation of posture control in rats with inferior olive lesions.Scientific reports · 2021Article
- Oculopalatal tremor following sequential medullary infarcts that did not cause hypertrophic olivary degeneration.Cerebellum & ataxias · 2020Article
- Purkinje Cell Representations of Behavior: Diary of a Busy Neuron.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Quasiperiodic rhythms of the inferior olive.PLoS computational biology · 2019Article
- Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications.Cerebellum (London, England) · 2019Article
- Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function.Nature methods · 2018Article
- Complex Spike Wars: a New Hope.Cerebellum (London, England) · 2018Review
- Climbing fibers predict movement kinematics and performance errors.Journal of neurophysiology · 2017Article
- Climbing Fibers Control Purkinje Cell Representations of Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper.Cerebellum (London, England) · 2017Article
- Cerebellar physiology: links between microcircuitry properties and sensorimotor functions.The Journal of physiology · 2017Review
- Heterogeneous Expression of T-type Ca(2+) Channels Defines Different Neuronal Populations in the Inferior Olive of the Mouse.Frontiers in cellular neuroscience · 2016Article
- The role of astrocyte mitochondria in differential regional susceptibility to environmental neurotoxicants: tools for understanding neurodegeneration.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- Neural circuits in movement control.The Journal of physiology · 2013Article
- Olivopontocerebellar degeneration associated with 3-hydroxy-3-methylglutaric aciduria in a domestic shorthair cat.JFMS open reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebellar climbing fibres originate in the inferior olive (IO). Temporary IO inactivation produces movement deficits. Does permanent inactivation produce similar deficits and, if so, do they recover? The excitotoxin, kainic acid, was injected into the rostral IO of three cats. Behaviour was measured during reaching and locomotion. Two cats were injected during the reaching task. Within minutes, grasping became difficult and the trajectories of the reaches showed higher arcing than normally seen. During locomotion, both cats showed head and trunk deviation to the injected side, walking paths curved to the injected side, and the paws were lifted higher than normal. Limbs contralateral to the injections became rigid. Within 1 day, posture had normalized, locomotion was unsteady and high lifting of the paws had reversed to a tendency to drag the dorsum of the paws. Passive body movement produced vestibular signs. Over a few days, locomotion normalized and vestibular signs disappeared. Reach trajectories were normal but grasping deficits persisted. Over the first week, the amplitude of limb lift during reaching and locomotion began to increase. The increase continued over time and, after several months, limb movements became severely ataxic. The effects followed the somatotopy of the rostral IO: a loss of cells in medial rostral IO only affected the forelimb, whereas a loss of cells in medial and lateral IO affected both forelimb and hindlimb. Deficits produced by IO lesions involve multiple mechanisms; some recover rapidly, some appear stable, and some worsen over time. The nature of the progressive deficit suggests a gradual loss of Purkinje cell inhibition on cerebellar nuclear cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.