ArticleThe Journal of physiology2012
Quantifying Ca2+ release and inactivation of Ca2+ release in fast- and slow-twitch muscles.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- JiSuJi, a virtual muscle for small animal simulations, accurately predicts force from naturalistic spike trains.bioRxiv : the preprint server for biology · 2025Article
- Comparison of Phasic Store-Operated Calcium Entry in Rat Slow- and Fast-Twitch Muscle Fibers.Acta physiologica (Oxford, England) · 2025Article
- Electrophysical cardiac remodeling at the molecular level: Insights into ryanodine receptor activation and calcium-induced calcium release from a stochastic explicit-particle model.Biophysical journal · 2024Article
- Influence of temperature on twitch potentiation following submaximal voluntary contractions in human plantar flexor muscles.Physiological reports · 2023Article
- Understanding altered contractile properties in advanced age: insights from a systematic muscle modelling approach.Biomechanics and modeling in mechanobiology · 2023Article
- A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers.The Journal of general physiology · 2022Article
- Ryanodine receptor leak triggers fiber CaScience advances · 2021Article
- Components of activation heat in skeletal muscle.Journal of muscle research and cell motility · 2021Article
- Cyclically producing the same average muscle-tendon force with a smaller duty increases metabolic rate.Proceedings. Biological sciences · 2020Article
- An Equivocal Final Link - Quantitative Determination of the Thermodynamic Efficiency of ATP Hydrolysis - Sullies the Chain of Electric, Ionic, Mechanical and Metabolic Steps Underlying Cardiac Contraction.Frontiers in physiology · 2020Article
- Metabolic Cost of Activation and Mechanical Efficiency of Mouse Soleus Muscle Fiber Bundles During Repetitive Concentric and Eccentric Contractions.Frontiers in physiology · 2019Article
- Does the intercept of the heat-stress relation provide an accurate estimate of cardiac activation heat?The Journal of physiology · 2017Article
- Doublet stimulation increases CaThe Journal of general physiology · 2017Article
- Children and adults minimise activated muscle volume by selecting gait parameters that balance gross mechanical power and work demands.The Journal of experimental biology · 2015Article
- Juxtaposition of the changes in intracellular calcium and force during staircase potentiation at 30 and 37°C.The Journal of general physiology · 2014Article
- Observation of the molecular organization of calcium release sites in fast- and slow-twitch skeletal muscle with nanoscale imaging.Journal of the Royal Society, Interface · 2014Article
- Intracellular calcium movements during relaxation and recovery of superfast muscle fibers of the toadfish swimbladder.The Journal of general physiology · 2014Article
- Efficiency and cross-bridge work output of skeletal muscle is decreased at low levels of activation.Pflugers Archiv : European journal of physiology · 2014Article
- Constraints on muscle performance provide a novel explanation for the scaling of posture in terrestrial animals.Biology letters · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of this study were to quantify the Ca(2+) release underlying twitch contractions of mammalian fast- and slow-twitch muscle and to comprehensively describe the transient inactivation of Ca(2+) release following a stimulus. Experiments were performed using bundles of fibres from mouse extensor digitorum longus (EDL) and soleus muscles. Ca(2+) release was quantified from the amount of ATP used to remove Ca(2+) from the myoplasm following stimulation. ATP turnover by crossbridges was blocked pharmacologically (N-benzyl-p-toluenesulphonamide for EDL, blebbistatin for soleus) and muscle heat production was used as an index of Ca(2+) pump ATP turnover. At 20°C, Ca(2+) release in response to a single stimulus was 34 and 84 μmol (kg muscle)(-1) for soleus and EDL, respectively, and increased with temperature (30°C: soleus, 61 μmol kg(-1); EDL, 168 μmol kg(-1)). Delivery of another stimulus within 100 ms of the first produced a smaller Ca(2+) release. The maximum magnitude of the decrease in Ca(2+) release was greater in EDL than soleus. Ca(2+) release recovered with an exponential time course which was faster in EDL (mean time constant at 20°C, 32.1 ms) than soleus (65.6 ms) and faster at 30°C than at 20°C. The amounts of Ca(2+) released and crossbridge cycles performed are consistent with a scheme in which Ca(2+) binding to troponin-C allowed an average of ∼1.7 crossbridge cycles in the two muscles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.