ArticleThe Journal of physiology2013
Long-term enhancement of synaptic transmission between antennal lobe and mushroom body in cultured Drosophila brain.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 43 citations in OpenAlex.
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- Effect of increasing levels of Leucaena leucocephala seeds to grass pellets on performance of grower rabbits.Tropical animal health and production · 2023Article
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- Local translation provides the asymmetric distribution of CaMKII required for associative memory formation.Current biology : CB · 2022Article
- Pairing-Dependent Plasticity in a Dissected Fly Brain Is Input-Specific and Requires Synaptic CaMKII Enrichment and Nighttime Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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- The Role of Dopamine in Associative Learning in Drosophila: An Updated Unified Model.Neuroscience bulletin · 2021Review
- Assessing olfactory, memory, social and circadian phenotypes associated with schizophrenia in a genetic model based on Rim.Translational psychiatry · 2021Article
- Carbon Monoxide, a Retrograde Messenger Generated in Postsynaptic Mushroom Body Neurons, Evokes Noncanonical Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- Recurrent loops: Incorporating prediction error and semantic/episodic theories into Drosophila associative memory models.Genes, brain, and behavior · 2019Review
- Dopamine release in mushroom bodies of the honey bee (Apis mellifera L.) in response to aversive stimulation.Scientific reports · 2018Article
- Synaptic depression induced by postsynaptic cAMP production in the Drosophila mushroom body calyx.The Journal of physiology · 2018Article
- A Drosophila ex vivo model of olfactory appetitive learning.Scientific reports · 2017Article
- Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity ineLife · 2017Article
- Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies.Nature communications · 2016Article
- Learning defects in Drosophila growth restricted chico mutants are caused by attenuated adenylyl cyclase activity.Molecular brain · 2016Article
- Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila.Neural plasticity · 2015Article
- Modulation of innate and learned sexual behaviors by the TRP channel Painless expressed in the fruit fly brain: behavioral genetic analysis and its implications.Frontiers in behavioral neuroscience · 2014Review
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5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, the mushroom body (MB) is a critical brain structure for olfactory associative learning. During aversive conditioning, the MBs are thought to associate odour signals, conveyed by projection neurons (PNs) from the antennal lobe (AL), with shock signals conveyed through ascending fibres of the ventral nerve cord (AFV). Although synaptic transmission between AL and MB might play a crucial role for olfactory associative learning, its physiological properties have not been examined directly. Using a cultured Drosophila brain expressing a Ca(2+) indicator in the MBs, we investigated synaptic transmission and plasticity at the AL-MB synapse. Following stimulation with a glass micro-electrode, AL-induced Ca(2+) responses in the MBs were mediated through Drosophila nicotinic acetylcholine receptors (dnAChRs), while AFV-induced Ca(2+) responses were mediated through Drosophila NMDA receptors (dNRs). AL-MB synaptic transmission was enhanced more than 2 h after the simultaneous 'associative-stimulation' of AL and AFV, and such long-term enhancement (LTE) was specifically formed at the AL-MB synapses but not at the AFV-MB synapses. AL-MB LTE was not induced by intense stimulation of the AL alone, and the LTE decays within 60 min after subsequent repetitive AL stimulation. These phenotypes of associativity, input specificity and persistence of AL-MB LTE are highly reminiscent of olfactory memory. Furthermore, similar to olfactory aversive memory, AL-MB LTE formation required activation of the Drosophila D1 dopamine receptor, DopR, along with dnAChR and dNR during associative stimulations. These physiological and genetic analogies indicate that AL-MB LTE might be a relevant cellular model for olfactory memory.
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