ReviewHandbook of experimental pharmacology2012
What a difference an X or Y makes: sex chromosomes, gene dose, and epigenetics in sexual differentiation.
Review in Handbook of experimental pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 113 citations in OpenAlex.
- Sex chromosome-dependent epigenetic regulation underlies sex-specific H4 acetylation at the aromatase promoter in the developing mouse amygdala.Biology of sex differences · 2026Article
- X-inactive-specific transcript: a long noncoding RNA with a complex role in sex differences in human disease.Biology of sex differences · 2024Review
- Deep Screening for X Chromosome Parent-of-Origin Effects on Neurobehavioral and Neuroanatomical Phenotypes in 47,XXY Klinefelter Syndrome.Biological psychiatry global open science · 2024Article
- A P2RY12 deficiency results in sex-specific cellular perturbations and sexually dimorphic behavioral anomalies.Journal of neuroinflammation · 2024Article
- XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner.Biology of sex differences · 2024Article
- XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner.Research square · 2023Article
- Review
- The Male-Biased Expression of miR-2954 Is Involved in the Male Pathway of Chicken Sex Differentiation.Cells · 2022Article
- Sex Differences in Mast Cell-Associated Disorders: A Life Span Perspective.Cold Spring Harbor perspectives in biology · 2022Review
- Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism.Clinical epigenetics · 2021Article
- The effects of early life stress on motivated behaviors: A role for gonadal hormones.Neuroscience and biobehavioral reviews · 2020Review
- Reference genome and transcriptome informed by the sex chromosome complement of the sample increase ability to detect sex differences in gene expression from RNA-Seq data.Biology of sex differences · 2020Article
- The role of sex in the genomics of human complex traits.Nature reviews. Genetics · 2019Review
- Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes.Stem cell research & therapy · 2019Article
- Sexual Dimorphism in the Age of Genomics: How, When, Where.Frontiers in cell and developmental biology · 2019Review
- Bridging Sex and Gender in Neuroscience by SheddingFrontiers in neuroscience · 2019Article
- Sex-Dependent Effects of Developmental Lead Exposure on the Brain.Frontiers in genetics · 2018Review
- Fertile offspring from sterile sex chromosome trisomic mice.Science (New York, N.Y.) · 2017Article
- Sex chromosomes drive gene expression and regulatory dimorphisms in mouse embryonic stem cells.Biology of sex differences · 2017Article
- Comparative analysis of MBD-seq and MeDIP-seq and estimation of gene expression changes in a rodent model of schizophrenia.Genomics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A modern general theory of sex determination and sexual differentiation identifies the factors that cause sexual bias in gene networks, leading to sex differences in physiology and disease. The primary sex-biasing factors are those encoded on the sex chromosomes that are inherently different in the male and female zygotes. These factors, and downstream factors such as gonadal hormones, act directly on tissues to produce sex differences and antagonize each other to reduce sex differences. Recent studies of mouse models such as the four core genotypes have begun to distinguish between the direct effects of sex chromosome complement (XX vs. XY) and hormonal effects. Several lines of evidence implicate epigenetic processes in the control of sex differences, although a great deal of information is needed about sex differences in the epigenome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.