ArticleMethods in molecular biology (Clifton, N.J.)2013
Digital images are data: and should be treated as such.
Article in Methods in molecular biology (Clifton, N.J.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Reflect: reporting guidelines for preclinical, translational and clinical fluorescence molecular imaging studies.Npj imaging · 2025Article
- How good are medical students and researchers in detecting duplications in digital images from research articles: a cross-sectional survey.Research integrity and peer review · 2025Article
- Article
- Using AI to write scholarly publications.Accountability in research · 2024Article
- Community-developed checklists for publishing images and image analyses.Nature methods · 2024Review
- Article
- Precision requirements and data compression in CryoEM/CryoET.Journal of structural biology · 2022Article
- Authorship Issues When Articles are Retracted Due to Research Misconduct and Then Resubmitted.Science and engineering ethics · 2022Article
- Deepfakes: A new threat to image fabrication in scientific publications?Patterns (New York, N.Y.) · 2022Article
- Article
- Reproducible image handling and analysis.The EMBO journal · 2021Article
- Article
- Tutorial: guidance for quantitative confocal microscopy.Nature protocols · 2020Review
- Effective image visualization for publications - a workflow using open access tools and concepts.F1000Research · 2020Article
- ImageJ for Partially and Fully Automated Analysis of Trypanosome Micrographs.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Quantitative pixel intensity- and color-based image analysis on minimally compressed files: implications for whole-slide imaging.Histochemistry and cell biology · 2019Article
- A beginner's guide to rigor and reproducibility in fluorescence imaging experiments.Molecular biology of the cell · 2018Article
- Ensuring the Quality, Fairness, and Integrity of Journal Peer Review: A Possible Role of Editors.Science and engineering ethics · 2016Article
- Visualization of endosome dynamics in living nerve terminals with four-dimensional fluorescence imaging.Journal of visualized experiments : JoVE · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The scientific community has become very concerned about inappropriate image manipulation. In journals that check figures after acceptance, 20-25% of the papers contained at least one figure that did not comply with the journal's instructions to authors. The scientific press continues to report a small, but steady stream of cases of fraudulent image manipulation. Inappropriate image manipulation taints the scientific record, damages trust within science, and degrades science's reputation with the general public. Scientists can learn from historians and photojournalists, who have provided a number of examples of attempts to alter or misrepresent the historical record. Scientists must remember that digital images are numerically sampled data that represent the state of a specific sample when examined with a specific instrument. These data should be carefully managed. Changes made to the original data need to be tracked like the protocols used for other experimental procedures. To avoid pitfalls, unexpected artifacts, and unintentional misrepresentation of the image data, a number of image processing guidelines are offered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.