ReviewCurrent opinion in rheumatology2012
The genetics of scleroderma: looking into the postgenomic era.
Review in Current opinion in rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Genetic and Genomic Analysis of Systemic Sclerosis: A Narrative Review of the Recent Advancement.JMA journal · 2026Review
- Genetics of systemic sclerosis.Journal of scleroderma and related disorders · 2020Review
- Genetic Interactions Affect Lung Function in Patients with Systemic Sclerosis.G3 (Bethesda, Md.) · 2020Article
- Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis.BMC medical genomics · 2019Article
- Deciphering the Potential Pharmaceutical Mechanism of GUI-ZHI-FU-LING-WAN on Systemic Sclerosis based on Systems Biology Approaches.Scientific reports · 2019Article
- Familial risk of systemic sclerosis and co-aggregation of autoimmune diseases in affected families.Arthritis research & therapy · 2016Article
- Transcriptomic Segregation of Human Autoantigens Useful for the Diagnosis of Autoimmune Diseases.Molecular diagnosis & therapy · 2016Review
- Epigenetics and Primary Biliary Cirrhosis: a Comprehensive Review and Implications for Autoimmunity.Clinical reviews in allergy & immunology · 2016Review
- Genetics, Epigenetics, and Genomics of Systemic Sclerosis.Rheumatic diseases clinics of North America · 2015Review
- Antinuclear antibody-negative systemic sclerosis.Seminars in arthritis and rheumatism · 2015Article
- A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis.Arthritis research & therapy · 2015Article
- Identification of NF-κB and PLCL2 as new susceptibility genes and highlights on a potential role of IRF8 through interferon signature modulation in systemic sclerosis.Arthritis research & therapy · 2015Article
- Recent advances in the genetics of systemic sclerosis: toward biological and clinical significance.Current rheumatology reports · 2015Review
- The roles of Egr-2 in autoimmune diseases.Inflammation · 2015Article
- Emerging roles of innate immune signaling and toll-like receptors in fibrosis and systemic sclerosis.Current rheumatology reports · 2015Review
- Pathogenesis of Systemic Sclerosis.Frontiers in immunology · 2015Review
- Personalized medicine in systemic sclerosis: facts and promises.Current rheumatology reports · 2014Review
- Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.American journal of human genetics · 2014Article
- Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis.ISRN rheumatology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
purpose of reviewThe last decade has seen enormous progress in understanding genetic associations of systemic sclerosis to explain the observed heritability. This review highlights the most recent findings and places them in the context of proposed functional roles. RECENT
findingsOver 30 genes and gene regions have now been identified as scleroderma susceptibility loci. These include both human leukocyte antigen (HLA) and non-HLA genes, most of which involve immune-related pathways and modifiers of immune function. Many of these associations have also been reported in other systemic autoimmune diseases and suggest that there are multiple autoimmunity genes resulting in disease occurrence. SUMMARY: In spite of these advances, only a small proportion of the heritability of systemic sclerosis has been explained. Ongoing studies include fine mapping and sequencing studies to identify causal variants, whereas other studies focus on functional consequences of these variants in order to identify the link between these genetic variants and disease susceptibility. Such knowledge should lead to more targeted and effective treatment in this disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.