ArticleCurrent opinion in genetics & development2012
Phenotypic models of evolution and development: geometry as destiny.
Article in Current opinion in genetics & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Generative epigenetic landscapes map the topology and topography of cell fates.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamical systems of fate and form in development.Seminars in cell & developmental biology · 2025Review
- A Framework for Investigating Rules of Life by Establishing Zones of Influence.Integrative and comparative biology · 2022Article
- Time and space in segmentation.Interface focus · 2021Article
- Article
- A damped oscillator imposes temporal order on posterior gap gene expression in Drosophila.PLoS biology · 2018Article
- Dynamic Maternal Gradients Control Timing and Shift-Rates for Drosophila Gap Gene Expression.PLoS computational biology · 2017Article
- Bridging Mechanistic and Phenomenological Models of Complex Biological Systems.PLoS computational biology · 2016Article
- Gap Gene Regulatory Dynamics Evolve along a Genotype Network.Molecular biology and evolution · 2016Article
- Predicting Ancestral Segmentation Phenotypes from Drosophila to Anopheles Using In Silico Evolution.PLoS genetics · 2016Article
- Evolution-development congruence in pattern formation dynamics: Bifurcations in gene expression and regulation of networks structures.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2016Article
- Critical Timing without a Timer for Embryonic Development.Biophysical journal · 2015Article
- Transcription factor competition allows embryonic stem cells to distinguish authentic signals from noise.Cell systems · 2015Article
- Dynamics of the slowing segmentation clock reveal alternating two-segment periodicity.Development (Cambridge, England) · 2015Article
- Signalling dynamics in vertebrate segmentation.Nature reviews. Molecular cell biology · 2014Review
- Bioattractors: dynamical systems theory and the evolution of regulatory processes.The Journal of physiology · 2014Review
- Classification of transient behaviours in a time-dependent toggle switch model.BMC systems biology · 2014Article
- Mechanisms and constraints shaping the evolution of body plan segmentation.The European physical journal. E, Soft matter · 2013Article
- The Comet Cometh: Evolving Developmental Systems.Biological theoryArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Quantitative models of development that consider all relevant genes typically are difficult to fit to embryonic data alone and have many redundant parameters. Computational evolution supplies models of phenotype with relatively few variables and parameters that allows the patterning dynamics to be reduced to a geometrical picture for how the state of a cell moves. The clock and wavefront model, that defines the phenotype of somitogenesis, can be represented as a sequence of two discrete dynamical transitions (bifurcations). The expression-time to space map for Hox genes and the posterior dominance rule are phenotypes that naturally follow from computational evolution without considering the genetics of Hox regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.