Evidence map›Paper›PMID 23026359›Full record

ReviewSeminars in nuclear medicine2012

Brain tumors.

Karl Herholz, Karl-Josef Langen, Christiaan Schiepers, James M Mountz

Abstract readReview
In one paragraph

Review in Seminars in nuclear medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Radiosynthesis and preclinical evaluation of aEJNMMI radiopharmacy and chemistry · 2024
    Article
  8. Review
  9. Review
  10. Preclinical and Clinical Use of Indigenously DevelopedACS pharmacology & translational science · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Karl HerholzSchool of Cancer and Enabling Sciences, The University of Manchester, Wolfson Molecular Imaging Centre, Manchester, England. karl.herholz@manchester.ac.uk
Karl-Josef Langen
Christiaan Schiepers
James M Mountz
Forschungszentrum Jülich · DEUniversity of California, Los Angeles · USUniversity of Manchester · GBUniversity of Pittsburgh · US

Funding

Quantitative Biomarker Imaging for Early Therapy Response Assessment in CancerU01CA140230 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOUNTZ, JAMES M. · 2009 to 2013
$2.1M
NCI NIH HHS U01 CA140230
6 · The paper itself

Abstract

This review addresses the specific contributions of nuclear medicine techniques, and especially positron emission tomography (PET), for diagnosis and management of brain tumors. (18)F-Fluorodeoxyglucose PET has particular strengths in predicting prognosis and differentiating cerebral lymphoma from nonmalignant lesions. Amino acid tracers including (11)C-methionine, (18)F-fluoroethyltyrosine, and (18)F-L-3,4-dihydroxyphenylalanine provide high sensitivity, which is most useful for detecting recurrent or residual gliomas, including most low-grade gliomas. They also play an increasing role for planning and monitoring of therapy. (18)F-fluorothymidine can only be used in tumors with absent or broken blood-brain barrier and has potential for tumor grading and monitoring of therapy. Ligands for somatostatin receptors are of particular interest in pituitary adenomas and meningiomas. Tracers to image neovascularization, hypoxia, and phospholipid synthesis are under investigation for potential clinical use. All methods provide the maximum of information when used with image registration and fusion display with contrast-enhanced magnetic resonance imaging scans. Integration of PET and magnetic resonance imaging with stereotactic neuronavigation systems allows the targeting of stereotactic biopsies to obtain a more accurate histologic diagnosis and better planning of conformal and stereotactic radiotherapy.

Indexed as

Brain NeoplasmsAnimalsHumansNuclear MedicineOpportunistic InfectionsRadiopharmaceuticalsTreatment OutcomeRadiopharmaceuticals

Identifiers

PMID23026359
PMCPMC3925448
OpenAlexW4211193121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.