ArticleContemporary clinical trials2013
A systems biology approach to studying Tai Chi, physiological complexity and healthy aging: design and rationale of a pragmatic randomized controlled trial.
Article in Contemporary clinical trials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Caring for Caregivers With Mind-body Exercise
Chiropractic Care for Episodic Migraine
Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Determining the safety and effectiveness of Tai Chi: a critical overview of 210 systematic reviews of controlled clinical trials.Systematic reviews · 2022Pooled it
- Reporting of Protocol Rationale and Content Validity in Randomized Clinical Trials of T'ai Chi: A Systematic Evaluation.Journal of alternative and complementary medicine (New York, N.Y.) · 2019Pooled it
- Tai Chi and Qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2018Pooled it
- The impact of Tai Chi and Qigong mind-body exercises on motor and non-motor function and quality of life in Parkinson's disease: A systematic review and meta-analysis.Parkinsonism & related disorders · 2017Pooled it
- Detrended Fluctuation Analysis of Gait Cycles: A Study of Neuromuscular and Ground Force Dynamics.Sensors (Basel, Switzerland) · 2025Trial
- Integrating Chiropractic Care and Tai Chi Training for the Treatment of Chronic Nonspecific Neck Pain in Nurses: A Single-Arm Mixed-Methods Pilot Trial.Journal of integrative and complementary medicine · 2024Trial
- Long-term Tai Chi practice in older adults is associated with "younger" functional abilities.Aging cell · 2024Trial
- A Randomized Trial of Tai Chi on Preventing Hypertension and Hyperlipidemia in Middle-Aged and Elderly Patients.International journal of environmental research and public health · 2021Trial
- Trial
- Multicomponent exercise training in cardiovascular complexity in prefrail older adults: a randomized blinded clinical pilot study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Trial
- Complexity-Based Measures of Heart Rate Dynamics in Older Adults Following Long- and Short-Term Tai Chi Training: Cross-sectional and Randomized Trial Studies.Scientific reports · 2019Trial
- Protocol for the MATCH study (Mindfulness and Tai Chi for cancer health): A preference-based multi-site randomized comparative effectiveness trial (CET) of Mindfulness-Based Cancer Recovery (MBCR) vs. Tai Chi/Qigong (TCQ) for cancer survivors.Contemporary clinical trials · 2017Trial
- Trial
- Use of pragmatic community-based interventions to enhance recruitment and adherence in a randomized trial of Tai Chi for women with osteopenia: insights from a qualitative substudy.Menopause (New York, N.Y.) · 2014Trial
- Trial
- Predicting fall risk among older adults with sarcopenia in China using machine learning models: a six-year longitudinal study from CHARLS.BMC geriatrics · 2026Article
- The Science of Tai Chi andJournal of integrative and complementary medicine · 2025Review
- Combined chiropractic care and Tai Chi for chronic neck pain: A protocol for a pilot randomized trial.Contemporary clinical trials communications · 2025Article
- 'Hidden' anger as a risk factor for operational health: An exploratory approach among French military personnel.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2025Article
- Quantification of changes in balance control with tasks and injury using detrending methods for time series analysis.Frontiers in bioengineering and biotechnology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
introductionAging is typically associated with progressive multi-system impairment that leads to decreased physical and cognitive function and reduced adaptability to stress. Due to its capacity to characterize complex dynamics within and between physiological systems, the emerging field of complex systems biology and its array of quantitative tools show great promise for improving our understanding of aging, monitoring senescence, and providing biomarkers for evaluating novel interventions, including promising mind-body exercises, that treat age-related disease and promote healthy aging. MATERIAL AND
methodsAn ongoing, two-arm randomized clinical trial is evaluating the potential of Tai Chi mind-body exercise to attenuate age-related loss of complexity. A total of 60 Tai Chi-naïve healthy older adults (aged 50-79) are being randomized to either six months of Tai Chi training (n=30), or to a waitlist control receiving unaltered usual medical care (n=30). Our primary outcomes are complexity-based measures of heart rate, standing postural sway and gait stride interval dynamics assessed at 3 and 6months. Multiscale entropy and detrended fluctuation analysis are used as entropy- and fractal-based measures of complexity, respectively. Secondary outcomes include measures of physical and psychological function and tests of physiological adaptability also assessed at 3 and 6months. DISCUSSION: Results of this study may lead to novel biomarkers that help us monitor and understand the physiological processes of aging and explore the potential benefits of Tai Chi and related mind-body exercises for healthy aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.