SynthesisEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2013
Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels.
Synthesis in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Changes in RNA expression levels during antidepressant treatment: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2021Pooled it
- The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies.Translational psychiatry · 2017Pooled it
- Leptin and leptin receptor gene polymorphisms and depression treatment response.Acta neuropsychiatrica · 2024Article
- Use of Serum Biomarkers to Aid Antidepressant Selection in Depressive Patients.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Article
- A Longitudinal Study of the Association between theInternational journal of molecular sciences · 2022Article
- HPA Axis in the Pathomechanism of Depression and Schizophrenia: New Therapeutic Strategies Based on Its Participation.Brain sciences · 2021Review
- Leptin polymorphism rs3828942: risk for anxiety disorders?European archives of psychiatry and clinical neuroscience · 2021Article
- Leptin Gene and Leptin Receptor Gene Polymorphisms in Alcohol Use Disorder: Findings Related to Psychopathology.Frontiers in psychiatry · 2021Article
- Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression.BioMed research international · 2017Article
- Pharmacogenetics and Imaging-Pharmacogenetics of Antidepressant Response: Towards Translational Strategies.CNS drugs · 2016Review
- Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders.Current psychiatry reports · 2015Review
- Search for common targets of lithium and valproic acid identifies novel epigenetic effects of lithium on the rat leptin receptor gene.Translational psychiatry · 2015Article
- Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates.Translational psychiatry · 2014Article
- Gut feelings about depression.Journal of psychiatry & neuroscience : JPN · 2014Article
- The impact of leptin on perinatal development and psychopathology.Journal of chemical neuroanatomy · 2014Review
- The Cerebellum and Premenstrual Dysphoric Disorder.AIMS neuroscience · 2014Article
- Mechanisms of antidepressant resistance.Frontiers in pharmacology · 2013Review
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Authors and funding
23 authors at 8 institutions in 4 countries.
Funding
Abstract
Leptin, a peptide hormone from adipose tissue and key player in weight regulation, has been suggested to be involved in sleep and cognition and to exert antidepressant-like effects, presumably via its action on the HPA-axis and hippocampal function. This led us to investigate whether genetic variants in the leptin gene, the level of leptin mRNA-expression and leptin serum concentrations are associated with response to antidepressant treatment. Our sample consisted of inpatients from the Munich Antidepressant Response Signature (MARS) project with weekly Hamilton Depression ratings, divided into two subsamples. In the exploratory sample (n=251) 17 single nucleotide polymorphisms (SNPs) covering the leptin gene region were genotyped. We found significant associations of several SNPs with impaired antidepressant treatment outcome and impaired cognitive performance after correction for multiple testing. The SNP (rs10487506) showing the highest association with treatment response (p=3.9×10(-5)) was analyzed in the replication sample (n=358) and the association could be verified (p=0.021) with response to tricyclic antidepressants. In an additional meta-analysis combining results from the MARS study with data from the Genome-based Therapeutic Drugs for Depression (GENDEP) and the Sequenced Treatment Alternatives to Relieve Depression (STAR(⁎)D) studies, nominal associations of several polymorphisms in the upstream vicinity of rs10487506 with treatment outcome were detected (p=0.001). In addition, we determined leptin mRNA expression in lymphocytes and leptin serum levels in subsamples of the MARS study. Unfavorable treatment outcome was accompanied with decreased leptin mRNA and leptin serum levels. Our results suggest an involvement of leptin in antidepressant action and cognitive function in depression with genetic polymorphisms in the leptin gene, decreased leptin gene expression and leptin deficiency in serum being risk factors for resistance to antidepressant therapy in depressed patients.
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