ArticleClinical science (London, England : 1979)2013
Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging.
Article in Clinical science (London, England : 1979), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Long-Term Aerobic Exercise Improves Vascular Function Into Old Age: A Systematic Review, Meta-Analysis and Meta Regression of Observational and Interventional Studies.Frontiers in physiology · 2019Pooled it
- Reducing effect of aerobic exercise on blood pressure of essential hypertensive patients: A meta-analysis.Medicine · 2017Pooled it
- The impact of age on vascular smooth muscle function in humans.Journal of hypertension · 2015Pooled it
- Combined Citrulline and Glutathione Supplementation Improves Endothelial Function and Blood Pressure Reactivity in Postmenopausal Women.Nutrients · 2023Trial
- Chronic nicotinamide riboside supplementation is well-tolerated and elevates NADNature communications · 2018Trial
- Impaired fasting blood glucose is associated with increased endothelin-1 vasoconstrictor tone.Atherosclerosis · 2013Trial
- Anthracycline chemotherapy, vascular dysfunction and cognitive impairment: burgeoning topics and future directions.Future cardiology · 2023Review
- Reduced Circulating Endothelial Progenitor Cells and Downregulated GTCPH I Pathway Related to Endothelial Dysfunction in Premenopausal Women with Isolated Impaired Glucose Tolerance.Cardiology research and practice · 2020Article
- Healthy lifestyle-based approaches for successful vascular aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Keynote lecture: strategies for optimal cardiovascular aging.American journal of physiology. Heart and circulatory physiology · 2018Article
- Aortic Response to Strength Training andFrontiers in physiology · 2018Article
- Aging-Induced Biological Changes and Cardiovascular Diseases.BioMed research international · 2018Review
- Nutrition and other lifestyle influences on arterial aging.Ageing research reviews · 2017Review
- Aerobic exercise improves measures of vascular health in diabetic peripheral neuropathy.The International journal of neuroscience · 2017Article
- Habitual aerobic exercise does not protect against micro- or macrovascular endothelial dysfunction in healthy estrogen-deficient postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Blunted increases in skin sympathetic nerve activity are related to attenuated reflex vasodilation in aged human skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice.Aging · 2016Article
- Melatonin as a Potential Agent in the Treatment of Sarcopenia.International journal of molecular sciences · 2016Review
- Review
- Association between pre hemodialysis serum sodium concentration and blood pressure: results from a retrospective analysis from the international monitoring dialysis outcomes (MONDO) initiative.Journal of human hypertension · 2016Article
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Abstract
In the present study, we tested the hypothesis that age-associated vascular endothelial dysfunction is exacerbated by IFG (impaired fasting plasma glucose) and that regular aerobic exercise prevents this effect. Data were analysed from a cohort of 131 non-smoking men and women without overt clinical disease. Compared with young adult controls (age=24±1 years, n=29; values are means±S.E.M.), brachial artery FMD (flow-mediated dilation), a measure of conduit artery EDD (endothelium-dependent dilation), was 33% lower [7.93±0.33 against 5.27±0.37%Δ (% change), P<0.05] in MA/O (middle-aged/older) adults with NFG (normal fasting plasma glucose) (≤99 mg/dl, 62±1 years, n=35). In MA/O adults with IFG (100-125 mg/dl, 64±1 years, n=28), FMD was 30% lower (3.37±0.35%Δ) than in their peers with NFG and 58% lower than young controls (P<0.05). Brachial artery FMD was greater (6.38±0.35%Δ) in MA/O adults with NFG who regularly performed aerobic exercise (>45 min/day for ≥5 days/week, 62±1 years, n=23) compared with their non-exercising peers and only slightly less than young controls (P<0.05). Most importantly, FMD was completely preserved in MA/O adults with IFG who regularly performed aerobic exercise (6.99±0.69%Δ, 65±1 years, n=16). In the pooled sample, fasting plasma glucose was inversely related to FMD (r=-0.42, P<0.01) and was the strongest independent predictor of FMD (R(2)=0.32). Group differences in FMD were not affected by other subject characteristics or brachial artery properties, including brachial artery dilation to sublingual NTG (nitroglycerine, i.e. endothelium-independent dilation). IFG exacerbates age-associated vascular endothelial dysfunction and this adverse effect is completely prevented in MA/O adults who regularly perform aerobic exercise.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.