ArticleEvolution; international journal of organic evolution2012
The cellular immune response of Daphnia magna under host-parasite genetic variation and variation in initial dose.
Article in Evolution; international journal of organic evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Trematode infection buffers heat stress in blue mussels Mytilus edulis: The role of heat shock proteins.The Journal of animal ecology · 2026Article
- Disentangling the role of parasite infectivity and density from host susceptibility in infection development and parasite proliferation.Biology letters · 2025Article
- Host genotype and infection status interact to shape microbiomes inParasitology · 2024Article
- A common multi-host parasite shows genetic structuring at the host species and population levels.Parasitology · 2024Article
- Genotypic variation in parasite avoidance behaviour and other mechanistic, nonlinear components of transmission.Proceedings. Biological sciences · 2019Article
- Host genotype-specific microbiota do not influence the susceptibility of D. magna to a bacterial pathogen.Scientific reports · 2018Article
- Environmental variation causes different (co) evolutionary routes to the same adaptive destination across parasite populations.Evolution letters · 2017Article
- Parasite transmission in a natural multihost-multiparasite community.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Article
- The bacterial parasite Pasteuria ramosa is not killed if it fails to infect: implications for coevolution.Ecology and evolution · 2013Article
- Daphnia magna shows reduced infection upon secondary exposure to a pathogen.Biology letters · 2012Article
- Epidemiology of a Daphnia-multiparasite system and its implications for the red queen.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In invertebrate-parasite systems, the likelihood of infection following parasite exposure is often dependent on the specific combination of host and parasite genotypes (termed genetic specificity). Genetic specificity can maintain diversity in host and parasite populations and is a major component of the Red Queen hypothesis. However, invertebrate immune systems are thought to only distinguish between broad classes of parasite. Using a natural host-parasite system with a well-established pattern of genetic specificity, the crustacean Daphnia magna and its bacterial parasite Pasteuria ramosa, we found that only hosts from susceptible host-parasite genetic combinations mounted a cellular response following exposure to the parasite. These data are compatible with the hypothesis that genetic specificity is attributable to barrier defenses at the site of infection (the gut), and that the systemic immune response is general, reporting the number of parasite spores entering the hemocoel. Further supporting this, we found that larger cellular responses occurred at higher initial parasite doses. By studying the natural infection route, where parasites must pass barrier defenses before interacting with systemic immune responses, these data shed light on which components of invertebrate defense underlie genetic specificity.
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