ArticleFrontiers in oncology2012
Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model.
Article in Frontiers in oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Modeling of Tumor Cell Adhesion, Extravasation, and Sorting in a Microvascular System.Advances in experimental medicine and biology · 2026Article
- Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions.Biophysical journal · 2025Article
- Mechanical deformation and death of circulating tumor cells in the bloodstream.Cancer metastasis reviews · 2024Review
- The progressive trend of modeling and drug screening systems of breast cancer bone metastasis.Journal of biological engineering · 2024Review
- Review
- Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes.Biophysical journal · 2022Article
- Detection of circulating tumor cells: opportunities and challenges.Biomarker research · 2022Review
- Biophysical interactions between components of the tumor microenvironment promote metastasis.Biophysical reviews · 2021Review
- Circulating prostate cancer cells have differential resistance to fluid shear stress-induced cell death.Journal of cell science · 2021Article
- Fluids and their mechanics in tumour transit: shaping metastasis.Nature reviews. Cancer · 2020Review
- Cathelicidin Suppresses Colon Cancer Metastasis via a P2RX7-Dependent Mechanism.Molecular therapy oncolytics · 2019Article
- The relationship between metastatic potential and in vitro mechanical properties of osteosarcoma cells.Molecular biology of the cell · 2019Article
- Image-based model of the spectrin cytoskeleton for red blood cell simulation.PLoS computational biology · 2017Article
- Effects of flowing RBCs on adhesion of a circulating tumor cell in microvessels.Biomechanics and modeling in mechanobiology · 2017Article
- Article
- Numerical simulation of a single cell passing through a narrow slit.Biomechanics and modeling in mechanobiology · 2016Article
- Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment.Advances in experimental medicine and biology · 2016Article
- Benchtop technologies for circulating tumor cells separation based on biophysical properties.BioMed research international · 2015Review
- Natural history of hepatic metastases from colorectal cancer--pathobiological pathways with clinical significance.World journal of gastroenterology · 2014Review
- Rolling in the deep: therapeutic targeting of circulating tumor cells.Frontiers in oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
It is inevitable for tumor cells to deal with various mechanical forces in order to move from primary to metastatic sites. In particular, the circulating tumor cells that have detached from the primary tumor and entered into the bloodstream need to survive in a completely new microenvironment. They must withstand hemodynamic forces and overcome the effects of fluid shear before they can leave the vascular system (extravasate) to establish new metastatic foci. One of the hypotheses of the tumor cell extravasation process is based on the so called "adhesion cascade" that was formulated and observed in the context of leukocytes circulating in the vascular system. During this process, the cell needs to switch between various locomotion strategies, from floating with the blood stream, to rolling on the endothelial wall, to tumor cell arrest and crawling, and finally tumor cell transmigration through the endothelial layer. The goal of this project is to use computational mechanical modeling to investigate the fundamental biophysical parameters of tumor cells in circulation. As a first step to build a robust in silico model, we consider a single cell exposed to the blood flow. We examine parameters related to structure of the actin network, cell nucleus and adhesion links between the tumor and endothelial cells that allow for successful transition between different transport modes of the adhesion cascade.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.