Evidence map›Paper›PMID 23024926›Full record

ArticleCurrent protocols in mouse biology2012

Methods for studying rodent intestinal lipoprotein production and metabolism.

Alison B Kohan, Philip N Howles, Patrick Tso

Abstract read
In one paragraph

Article in Current protocols in mouse biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Development of a novel murine model of lymphatic metastasis.Clinical & experimental metastasis · 2020
    Article
  6. Review
  7. Article
  8. Effect of mono- and diglycerides on the digestion and absorption of lutein in lymph fistula rats.American journal of physiology. Gastrointestinal and liver physiology · 2018
    Article
  9. Article
  10. Article
  11. Article
  12. Apolipoprotein A-V deficiency enhances chylomicron production in lymph fistula mice.American journal of physiology. Gastrointestinal and liver physiology · 2015
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alison B KohanDepartment of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, 45237.
Philip N Howles
Patrick Tso
University of Cincinnati · US

Funding

LIPID, LIPOPROTEIN, AND GLUCOSE METABOLISM COREU24DK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2001 to 2015
$12.9M
Lipid profile, lipoprotein and apolipoprotein composition, and intestinal fat absorption efficiency in germ-free and conventional miceU2CDK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN · 2016 to 2021
$4.9M
Functional & molecular study of intetinal cholesterol transporters & absorptionR01DK076928 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2007 to 2011
$1.6M
Carboxyl Ester Lipase Affects Hepatic HDL MetabolismR01HL078900 · NHLBI · UNIVERSITY OF CINCINNATI · PI HOWLES, PHILIP N · 2006 to 2009
$1.6M
Physiological Role of NPC1L1 in Lipid Transport and MetabolismR01DK076907 · NIDDK · UNIVERSITY OF CINCINNATI · PI HUI, DAVID YIU-KWAN · 2007 to 2010
$1.3M
Role of NPC1L1 in regulating energy metabolism, nutrient utilization & weight gaiR01DK077170 · NIDDK · UNIVERSITY OF CINCINNATI · PI HOWLES, PHILIP N · 2009 to 2010
$720k
The regulation of hepatic lipid metabolism by apolipoprotein AIVF32DK091173 · NIDDK · UNIVERSITY OF CINCINNATI · PI KOHAN, ALISON BLOOM · 2011 to 2013
$147k
NHLBI NIH HHS R01 HL078900NIDDK NIH HHS F32 DK091173NIDDK NIH HHS R01 DK076907NIDDK NIH HHS R01 DK076928NIDDK NIH HHS R01 DK077170NIDDK NIH HHS U24 DK059630NIDDK NIH HHS U2C DK059630
6 · The paper itself

Abstract

Lipid absorption begins with the digestion of dietary triacylglycerol and ultimately results in the secretion of triacylglycerol in chylomicrons into the lymphatics. Additionally, the intestine also secretes numerous proteins and peptides involved in lipid and lipoprotein metabolism in response to food. Ultimately, chylomicrons and these proteins, peptides, and hormones are found in lymph. The lymph fistula rat model has traditionally been used to study this intestinal absorption of nutrients, especially lipids, but recently, this model has also been used for studying the secretion of hormones by the small intestine. The protocols described in this article include the lymph fistula rat and mouse model, as well as in vivo chylomicron metabolism studies. These experimental models are helpful for the study of metabolic phenotypes, the characterization of intestinal lipid absorption and transport, and determining peripheral metabolism of intestinally derived lipoproteins.

Identifiers

PMID23024926
PMCPMC3458698
OpenAlexW1497095586

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.