ArticlePloS one2012
Asymptomatic endemic Chlamydia pecorum infections reduce growth rates in calves by up to 48 percent.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- From models to medicine: systematic development and evaluation of animal models forFrontiers in immunology · 2026Review
- The relationships of viral and protozoal co-infections to Chlamydia pecorum infection and chlamydiosis outcomes in northern koalas (Phascolarctos cinereus).PLoS pathogens · 2025Article
- Chlamydia in farms located in the Argentine-Brazilian-Paraguay tri-border.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Seroprevalence and Risk Factors ofAnimals : an open access journal from MDPI · 2023Article
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- Article
- Characterization of theInfection and immunity · 2018Article
- A novel synthetic peptide microarray assay detects Chlamydia species-specific antibodies in animal and human sera.Scientific reports · 2018Article
- Molecular and serological dynamics ofPeerJ · 2018Article
- Productive and Penicillin-StressedFrontiers in cellular and infection microbiology · 2017Article
- Humoral immune response against two surface antigens of Chlamydia pecorum in vaccinated and naturally infected sheep.PloS one · 2017Article
- Chlamydia gallinacea, not C. psittaci, is the endemic chlamydial species in chicken (Gallus gallus).Scientific reports · 2016Article
- Penicillin G-Induced Chlamydial Stress Response in a Porcine Strain of Chlamydia pecorum.International journal of microbiology · 2016Article
- Acute phase proteins as local biomarkers of respiratory infection in calves.BMC veterinary research · 2015Article
- Genetic and antigenic analysis of Chlamydia pecorum strains isolated from calves with diarrhea.The Journal of veterinary medical science · 2015Article
- Defining species-specific immunodominant B cell epitopes for molecular serology of Chlamydia species.Clinical and vaccine immunology : CVI · 2015Article
- Article
- Molecular and pathological insights into Chlamydia pecorum-associated sporadic bovine encephalomyelitis (SBE) in Western Australia.BMC veterinary research · 2014Article
- Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes.BMC genomics · 2014Article
- Host adaptation of Chlamydia pecorum towards low virulence evident in co-evolution of the ompA, incA, and ORF663 Loci.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular Chlamydia (C.) bacteria cause in cattle some acute but rare diseases such as abortion, sporadic bovine encephalomyelitis, kerato-conjunctivitis, pneumonia, enteritis and polyarthritis. More frequent, essentially ubiquitous worldwide, are low-level, asymptomatic chlamydial infections in cattle. We investigated the impact of these naturally acquired infections in a cohort of 51 female Holstein and Jersey calves from birth to 15 weeks of age. In biweekly sampling, we measured blood/plasma markers of health and infection and analyzed their association with clinical appearance and growth in dependence of chlamydial infection intensity as determined by mucosal chlamydial burden or contemporaneous anti-chlamydial plasma IgM. Chlamydia 23S rRNA gene PCR and ompA genotyping identified only C. pecorum (strains 1710S, Maeda, and novel strain Smith3v8) in conjunctival and vaginal swabs. All calves acquired the infection but remained clinically asymptomatic. High chlamydial infection associated with reduction of body weight gains by up to 48% and increased conjunctival reddening (P<10(-4)). Simultaneously decreased plasma albumin and increased globulin (P<10(-4)) suggested liver injury by inflammatory mediators as mechanisms for the growth inhibition. This was confirmed by the reduction of plasma insulin like growth factor-1 at high chlamydial infection intensity (P<10(-4)). High anti-C. pecorum IgM associated eight weeks later with 66% increased growth (P = 0.027), indicating a potential for immune protection from C. pecorum-mediated growth depression. The worldwide prevalence of chlamydiae in livestock and their high susceptibility to common feed-additive antibiotics suggests the possibility that suppression of chlamydial infections may be a major contributor to the growth promoting effect of feed-additive antibiotics.
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